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2.1.1.41: sterol 24-C-methyltransferase

This is an abbreviated version!
For detailed information about sterol 24-C-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.41

Reaction

S-adenosyl-L-methionine
+
5alpha-cholesta-8,24-dien-3beta-ol
=
S-adenosyl-L-homocysteine
 +
24-methylene-5alpha-cholest-8-en-3beta-ol

Synonyms

(S)-adenosyl-L-methionine:DELTA24(25)-sterol methyl transferase, 24-C-sterol methyltransferase, 24-SMT, 24-sterol C-methyltransferase, C-24 sterol methyltransferase, C24-methyltransferase, DELTA(24,25)-SMT, DELTA24-methyltransferase, DELTA24-sterol methyltransferase, Erg6, Erg6p, LMJF_36_2380, LMJF_36_2390, methyltransferase, DELTA24-sterol, PbSMT, phytosterol methyltransferase, S-adenosyl-4-methionine:sterol DELTA24-methyltransferase, S-adenosyl-L-methionine:DELTA24(23)-sterol methyltransferase, SAM:SMT, SMT, SMT protein, SMT1, SMT80, SMT90, sterol 24-C-methyltransferase, sterol C24-methyltransferase, sterol methyltransferase, STM, TbSMT, zymosterol 24-methyltransferase, zymosterol-24-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.41 sterol 24-C-methyltransferase

Inhibitors

Inhibitors on EC 2.1.1.41 - sterol 24-C-methyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(24,S),25-epiminozymosterol
-
-
(24R)-methyl-25-thiacholesteryl iodide
-
-
(24R,S),25-epiminolanosterol
-
-
(24R,S),25-epiminozymosterol
-
-
(24S)-methyl-25-thiacholesteryl iodide
-
-
(3beta,24,R,S)-24-methyl-24-thioniacholest-5-enol
-
-
(3S,20R)-20-(propylamino-ethyl)-pregn-7-en-3-ol
-
-
(3S,20S)-20-(butylamino-methyl)-pregn-7-en-3-ol
-
-
(3S,20S)-20-(ethylamino-methyl)-pregn-7-en-3-ol
-
-
(3S,20S)-20-(methylamino-methyl)-pregn-7-en-3-ol
-
-
(3S,20S)-20-(pentylamino-methyl)-pregn-7-en-3-ol
-
-
(3S,20S)-20-(propylamino-methyl)-pregn-7-en-3-ol
-
-
(3S,20S)-20-[(1R,S)-(1,2-dimethyl-propylamino)-methyl]-pregn-7-en-3-ol
-
-
(3S,20S)-20-[(2-dimethylamino-ethylamino)-methyl]-pregn-7-en-3-ol
-
-
(3S,20S)-20-[(2-methylpropyl)amino-methyl]-pregn-7-en-3-ol
-
-
(3S,20S)-20-[(2-pyrrolidin-1-yl-ethylamino)-methyl]-pregn-7-en-3-ol
-
-
(3S,20S)-20-[(3-dimethylamino-propylamino)-methyl]-pregn-7-en-3-ol
-
-
(R,S)-24,25-epiminolanosterol
-
-
(R,S)-S-butyl-S-[(3S,20S)-(3-hydroxypregn-7-en-20-yl)-methyl]-S-methyl-sulfonium iodide
-
-
2-(3S,20R)-[(E)-2-(3-hydroxypregn-7-en-20-yl)-ethenyl]-1-methylpyridinium iodide
-
-
22,25-Diazacholesterol
-
20R and 20S isomer
22,26-azasterol
22-piperidin-3-yl-pregnan-22(S),3beta-diol
-
-
23-Azacholesterol
24(R,S),25-epiminolanosterol
24(R,S),25-epiminozymosterol
-
reversible inhibitor, disrupts ergosterol homoeostasis by interrupting methyl addition to C-24 thereby impairing growth
24(R,S)-25-epiminolanosterol
-
-
24(S)-24-methyl-25-thiacholest-5-enol iodide
-
-
24-Azacholesterol
-
-
24-thialanosterol
-
-
24beta-aminolanosterol
-
-
25-aminolanosterol
-
-
25-aza-24,25-dihydrolanosterol
-
-
25-Aza-24,25-dihydrozymosterol
-
-
25-azacholestane
-
-
25-Azacholestanol
-
-
25-Azacholesterol
-
-
25-Azacholesterol hydrochloride
-
-
25-azalanosterol
25-thiacholesterol iodide
-
-
25-thialanosterol iodide
-
-
26,27-dehydrolanosterol
-
-
26,27-dehydrozymosterol
26-nor-25-thialanosterol
-
-
3-aminolanosterol
-
-
30-amino-24,25-dihydrolanosterol
-
-
4-(3S,20R)-[(E)-2-(3-hydroxypregn-7-en-20-yl)-ethenyl]-1-methylpyridinium iodide
-
-
5'-deoxy-5'-(methylthio)adenosine
-
AdoMet analog, competitive inhibitor
7-amino-24,25-dihydrolanosterol
-
-
Amphotericin B
-
-
amphotericine B
-
inhibits the wild-type at concentrations above 60 nM, inhibition can be hindered by zymosterol
cholesta-8,24(28)-dienol
-
-
desmosterol
ergosta-5,7,22-trienol
-
-
ergosterol
Filipin
-
slightly inhibiting at low concentration
itraconazole
-
-
ketoconazole
methyl ([2-[(3S,8S,9S,10R,13S,14S,17R)-3-(acetyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]propyl]amino)acetate
-
-
methyl 3-([2-[(3S,8S,9S,10R,13S,14S,17R)-3-(acetyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]propyl]amino)propanoate
-
-
methyl 4-([2-[(3S,8S,9S,10R,13S,14S,17R)-3-(acetyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]propyl]amino)butanoate
-
-
methyl 5-([2-[(3S,8S,9S,10R,13S,14S,17R)-3-(acetyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]propyl]amino)pentanoate
-
-
methyl 6-([2-[(3S,8S,9S,10R,13S,14S,17R)-3-(acetyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]propyl]amino)hexanoate
-
-
methyl 7-([2-[(3S,8S,9S,10R,13S,14S,17R)-3-(acetyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]propyl]amino)heptanoate
-
-
methyl 8-([2-[(3S,8S,9S,10R,13S,14S,17R)-3-(acetyloxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]propyl]amino)octanoate
-
-
Nystatin
-
slightly inhibiting at low concentration
S-adenosyl-L-homocysteine
-
-
S-isobutyladenosine
-
AdoMet analog, competitive inhibitor
sinefungin
-
AdoMet analog, competitive inhibitor
Substrate analogues
-
dead-end inhibitors
-
Triparanol
-
-
Zymosterol
additional information
-