2.1.1.4: acetylserotonin O-methyltransferase
This is an abbreviated version!
For detailed information about acetylserotonin O-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.4
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2.1.1.4
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melatonin
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pineal
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n-acetyltransferase
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rhythm
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retina
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circadian
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nocturnal
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night
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arylalkylamine
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pinealocytes
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diurnal
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photoreceptors
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photoperiodic
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melatoninergic
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harderian
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melatonin-synthesizing
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daytime
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nighttime
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5-hydroxytryptophan
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aa-nat
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arylalkylamine-n-acetyltransferase
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5-methoxytryptophan
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5-methoxytryptamine
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5-hydroxyindole
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n-acetyl-5-methoxytryptamine
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pinealectomized
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serotonin-n-acetyltransferase
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5-hydroxyindoleacetic
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5-methoxyindoles
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analysis
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light:dark
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synthesis
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ganglionectomy
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extrapineal
- 2.1.1.4
- melatonin
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pineal
- n-acetyltransferase
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rhythm
- retina
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circadian
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nocturnal
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night
- arylalkylamine
- pinealocytes
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diurnal
- photoreceptors
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photoperiodic
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melatoninergic
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harderian
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melatonin-synthesizing
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daytime
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nighttime
- 5-hydroxytryptophan
- aa-nat
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arylalkylamine-n-acetyltransferase
- 5-methoxytryptophan
- 5-methoxytryptamine
- 5-hydroxyindole
- n-acetyl-5-methoxytryptamine
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pinealectomized
- serotonin-n-acetyltransferase
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5-hydroxyindoleacetic
- 5-methoxyindoles
- analysis
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light:dark
- synthesis
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ganglionectomy
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extrapineal
Reaction
Synonyms
acetylserotonin methyltransferase, ASMT, ASMT1, ASMT2, COMT, HIOMT, hydroxindole-O-methyltransferase, hydroxyindole methyltransferase, hydroxyindole O-methyltransferase, hydroxyindole-O-methyl transferase, hydroxyindole-O-methyltransferase, MANES_17G050500, methyltransferase, acetylserotonin, N-acetylserotonin methyltransferase, N-acetylserotonin methyltransferase1, N-acetylserotonin O-methyltransferase
ECTree
2.1.1.4 acetylserotonin O-methyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.1.1.4 - acetylserotonin O-methyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-hydroxy-N-acetyltryptamine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + N-acetyl-4-methoxytryptamine
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8% of the activity with N-acetylserotonin
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-
?
5-hydroxyindoleacetic acid + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + 5-methoxyindoleacetic acid
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12% of the activity with N-acetylserotonin
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-
?
bufotenine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + N,N-dimethyl-5-hydroxytryptamine
N-acetylserotonin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
N-methylserotonin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + N-methyl-5-methoxytryptamine
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9% of the activity with N-acetylserotonin
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-
?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
bufotenine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + N,N-dimethyl-5-hydroxytryptamine
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-
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?
bufotenine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + N,N-dimethyl-5-hydroxytryptamine
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14% of the activity with N-acetylserotonin
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-
?
bufotenine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + N,N-dimethyl-5-hydroxytryptamine
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-
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-
?
N-acetylserotonin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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formation of the hormone melatonin
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-
?
N-acetylserotonin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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formation of the hormone melatonin
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-
?
N-acetylserotonin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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formation of the hormone melatonin
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-
?
N-acetylserotonin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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-
-
-
?
N-acetylserotonin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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formation of the hormone melatonin
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-
?
N-acetylserotonin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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formation of the hormone melatonin
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-
?
N-acetylserotonin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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-
-
-
?
N-acetylserotonin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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formation of the hormone melatonin
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-
?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + melatonin
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + melatonin
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + melatonin
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + melatonin
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + melatonin
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the enzyme is involved in melatonin biosynthesis in egg yolk, overview
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + melatonin
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + melatonin
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + melatonin
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + melatonin
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + melatonin
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + melatonin
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
Frog
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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-
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?
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
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-
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?
S-adenosyl-L-methionine + serotonin
S-adenosyl-L-homocysteine + 5-methoxytryptamine
enzyme AtASMT also O-methylates serotonin to produce 5-methoxytryptamine
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-
?
S-adenosyl-L-methionine + serotonin
S-adenosyl-L-homocysteine + 5-methoxytryptamine
enzyme AtASMT also O-methylates serotonin to produce 5-methoxytryptamine
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?
serotonin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + 5-methoxytryptamine
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-
-
-
?
serotonin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + 5-methoxytryptamine
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7% of the activity with N-acetylserotonin
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-
?
serotonin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + 5-methoxytryptamine
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-
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?
additional information
?
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caffeic acid O-methyltransferase (COMT), EC 2.1.1.68, methylates N-acetylserotonin into melatonin, it has N-acetylserotonin O-methyltransferase (ASMT) activity. COMT is a multifunctional enzyme methylating a diverse array of substrates, including phenylpropanoids, flavonoids, and arylalkylamines
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?
additional information
?
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caffeic acid O-methyltransferase (COMT), EC 2.1.1.68, methylates N-acetylserotonin into melatonin, it has N-acetylserotonin O-methyltransferase (ASMT) activity. COMT is a multifunctional enzyme methylating a diverse array of substrates, including phenylpropanoids, flavonoids, and arylalkylamines
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?
additional information
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the AtASMT protein catalyzes the conversion of N-acetylserotonin to melatonin and serotonin to 5-methoxytryptamine, respectively. The enzyme exhibits no caffeic acid O-methyltransferase activity, suggesting that its function is highly specific to melatonin synthesis
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?
additional information
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the AtASMT protein catalyzes the conversion of N-acetylserotonin to melatonin and serotonin to 5-methoxytryptamine, respectively. The enzyme exhibits no caffeic acid O-methyltransferase activity, suggesting that its function is highly specific to melatonin synthesis
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-
?
additional information
?
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caffeic acid O-methyltransferase (COMT), EC 2.1.1.68, methylates N-acetylserotonin into melatonin, it has N-acetylserotonin O-methyltransferase (ASMT) activity. COMT is a multifunctional enzyme methylating a diverse array of substrates, including phenylpropanoids, flavonoids, and arylalkylamines
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-
?
additional information
?
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the AtASMT protein catalyzes the conversion of N-acetylserotonin to melatonin and serotonin to 5-methoxytryptamine, respectively. The enzyme exhibits no caffeic acid O-methyltransferase activity, suggesting that its function is highly specific to melatonin synthesis
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-
?
additional information
?
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caffeic acid is no substrate
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?
additional information
?
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bovine enzyme has high specificity towards N-acetylserotonin, chicken enzyme methylates N-acetylserotonin and to some extent serotonin and bufotenine
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?
additional information
?
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bovine enzyme has high specificity towards N-acetylserotonin, chicken enzyme methylates N-acetylserotonin and to some extent serotonin and bufotenine
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?
additional information
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the enzyme also catalyzes the conversion of 5-hydroxyindoleacetate to 5-methoxyindoleacetate
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?
additional information
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absolute requirement for S-adenosylmethionine
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?
additional information
?
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caffeic acid O-methyltransferase (COMT), EC 2.1.1.68, methylates N-acetylserotonin into melatonin, it has N-acetylserotonin O-methyltransferase (ASMT) activity. The ASMT activity (Vmax/Km) of OsCOMT is 609fold higher than that of rice ASMT1
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-
?
additional information
?
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caffeic acid O-methyltransferase (COMT), EC 2.1.1.68, methylates N-acetylserotonin into melatonin, it has N-acetylserotonin O-methyltransferase (ASMT) activity. The ASMT activity (Vmax/Km) of OsCOMT is 609fold higher than that of rice ASMT1
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?
additional information
?
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activity is controlled by the endogenous clock
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?
additional information
?
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in pineal glands isolated in the morning 4 h magnetic field exposure changes melatonin release by affecting the signal transduction pathway leading from the norepinephrine receptor to N-acetyltransferase and hydroxyindole-O-methyltransferase and not via a direct effect at the enzyme levels
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?
additional information
?
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in pineal glands isolated in the morning 4 h magnetic field exposure changes melatonin release by affecting the signal transduction pathway leading from the norepinephrine receptor to N-acetyltransferase and hydroxyindole-O-methyltransferase and not via a direct effect at the enzyme levels
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?
