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2.1.1.4: acetylserotonin O-methyltransferase

This is an abbreviated version!
For detailed information about acetylserotonin O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.4

Reaction

S-adenosyl-L-methionine
+
N-acetylserotonin
=
S-adenosyl-L-homocysteine
 +
Melatonin

Synonyms

acetylserotonin methyltransferase, ASMT, ASMT1, ASMT2, COMT, HIOMT, hydroxindole-O-methyltransferase, hydroxyindole methyltransferase, hydroxyindole O-methyltransferase, hydroxyindole-O-methyl transferase, hydroxyindole-O-methyltransferase, MANES_17G050500, methyltransferase, acetylserotonin, N-acetylserotonin methyltransferase, N-acetylserotonin methyltransferase1, N-acetylserotonin O-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.4 acetylserotonin O-methyltransferase

Expression

Expression on EC 2.1.1.4 - acetylserotonin O-methyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
AtASMT transcripts are induced by cadmium treatment in Arabidopsis thaliana followed by increased melatonin synthesis
enzyme-associated melatonin levels increase as temperature increases when rice seedlings are exposed to various temperatures for 1 hr, but temperature-dependent increase in melatonin synthesis is only closely associated with an increase in both SNAT and ASMT activities, but not with transcript levels of melatonin biosynthetic genes. The relative melatonin levels are higher in the dark, exposure of rice seedlings to 1 hr darkness at 55°C results in a melatonin yield of 4.9 ng/g fresh weight, compared with 2.95 ng/g fresh weight under light conditions
-
In retinal cells the mutation of the YY1-binding site decreases the HIOMT promoter activity by 70%
-
significant daily rhythms of mRNA in pineal gland, liver and hindgut
-
the expression level in submandibular gland is higher in the dark period compared with the light period
-
the mRNA expression for HIOMT is only slightly increased at day 0 upon ulcer induction when compared with that in the intact mucosa, but at day 8 after ulcer formation, this expression of HIOMT is significantly enhanced, particularly at the ulcer areas in rats treated with melatonin or L-tryptophan
-
the rat Crx transcription factor is able to activate the HIOMT promoter in transfected HEK-293 cells
-
the transcripts of transcriptional activator WRKY79, heat-shock transcription factor Hsf20, and ASMT2 are all regulated by a 22-amino acid flagellin peptide (flg22) and by Xanthomonas axonopodis pv manihotis
there is an age-related decline in rat extrapineal melatonin synthesis with a consequent HIOMT functionality decrease in spleen, liver and heart during physiological aging, in the thymus HIOMT expression reveals no significant alterations with age
-