2.1.1.37: DNA (cytosine-5-)-methyltransferase
This is an abbreviated version!
For detailed information about DNA (cytosine-5-)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.37
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2.1.1.37
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histone
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methyltransferases
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cpg
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hypermethylation
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demethylation
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chromatin
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leukemia
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myeloid
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deacetylase
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dnmts
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5-aza-2'-deoxycytidine
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bisulfite
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tumorigenesis
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carcinogenesis
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5-azacytidine
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methylation-specific
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hematopoietic
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myelodysplastic
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imprint
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unmethylated
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5-methylcytosine
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mtases
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decitabine
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hdacs
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endonuclease
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hematologic
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cytogenetic
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epigenome
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pluripotent
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restriction-modification
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methylome
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trimethylation
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trichostatin
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blastocyst
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re-expression
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heterochromatin
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o6-methylguanine
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centromeric
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nanog
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p16ink4a
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cdh1
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flt3-itd
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adomet
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polycomb
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methylation-sensitive
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leukemogenesis
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rassf1a
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h3k9me3
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biotechnology
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line-1
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hpaii
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drug development
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analysis
- 2.1.1.37
- histone
- methyltransferases
- cpg
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hypermethylation
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demethylation
- chromatin
- leukemia
- myeloid
- deacetylase
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dnmts
- 5-aza-2'-deoxycytidine
- bisulfite
- tumorigenesis
- carcinogenesis
- 5-azacytidine
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methylation-specific
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hematopoietic
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myelodysplastic
-
imprint
-
unmethylated
- 5-methylcytosine
- mtases
- decitabine
- hdacs
- endonuclease
- hematologic
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cytogenetic
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epigenome
-
pluripotent
-
restriction-modification
-
methylome
-
trimethylation
-
trichostatin
- blastocyst
-
re-expression
- heterochromatin
- o6-methylguanine
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centromeric
-
nanog
- p16ink4a
- cdh1
-
flt3-itd
- adomet
-
polycomb
-
methylation-sensitive
-
leukemogenesis
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rassf1a
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h3k9me3
- biotechnology
-
line-1
- hpaii
- drug development
- analysis
Reaction
Synonyms
5-cytosine DNA methyltransferase, C5 MTase, C5-MTase, CG recognizing DNA methyltransferase SssI, CMT1, CMT3, cytosine 5-methyltransferase, cytosine carbon 5 DNA methyltransferase, cytosine DNA methylase, cytosine DNA methyltransferase, cytosine DNA MTase, cytosine-5 methyltransferase, cytosine-specific DNA methyltransferase, DCM, DCMT, deoxyribonucleate methylase, deoxyribonucleate methyltransferase, deoxyribonucleic (cytosine-5-)-methyltransferase, deoxyribonucleic acid (cytosine-5-)-methyltransferase, deoxyribonucleic acid methylase, deoxyribonucleic acid methyltransferase, deoxyribonucleic acid modification methylase, deoxyribonucleic methylase, DMT1, DNA (cytosine-5) methyltransferase, DNA (cytosine-5)-methyltransferase 1, DNA (cytosine-5)-methyltransferase 2, DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3B, DNA (cytosine-5-)-methyltransferase 3A, DNA (cytosine-C5) methyltransferase, DNA 5-cytosine methylase, DNA cytosine C(5)-methyltransferase, DNA cytosine c5 methylase, DNA cytosine methylase, DNA cytosine methyltransferase, DNA cytosine-5 methyltransferase 1, DNA cytosine-5-methyltransferase 1, DNA cytosine-5-methyltransferase 3A, DNA cytosine-5-methyltransferase 3B, DNA methylase, DNA methyltransferase, DNA methyltransferase 1, DNA methyltransferase 3a, DNA methyltransferase-1, DNA MTase, DNA transmethylase, DNA-cytosine 5-methylase, DNA-cytosine methyltransferase, DNA-methyltransferase, DNMT, Dnmt1, Dnmt1 DNA-(cytosine-C5)-methyltransferase, DNMT1 methyltransferase, Dnmt1o, Dnmt2, Dnmt3, Dnmt3a, DNMT3B, DNMT3b2, DNMTB, DRM1/2, EC 2.1.1.73, EcoRI methylase, EcoRII DNA-cytosine methylase, EhMeth, hDNMT1, hhaIM, HpaII, M.BssHII, M.BsuRIa, M.BsuRIb, M.EcoHK31l, M.HhaI, M.HhaIII, M.MpeI, M.MspI, M.SsoII, M.Ssp6803I, M.SssI, MarII, MET1, MET1B, methylphosphotriester-DNA methyltransferase, methyltransferase, deoxyribonucleate, More, MspI DNA methyltransferase, MYPE4940, NSUN2, Nt-DRM1, SinI DNA methyltransferase, SsoII, ssoIIM, SSSI, sssIM, ssssIM, type II DNA methylase, Z2389, Zmt3
ECTree
2.1.1.37 DNA (cytosine-5-)-methyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.1.1.37 - DNA (cytosine-5-)-methyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNA GC content, CpG frequency and methylation status, overview
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-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNA GC content, CpG frequency and methylation status, overview
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-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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-
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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-
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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-
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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the enzyme has distinct target sequences but no preferred methylation sites of promoters or other regulatory elements
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
the Z2389 DNAcytosine methyltransferase confers full protection to NotI sites by methylation of the first cytosine residue
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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-
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNA GC content, CpG frequency and methylation status, overview
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-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNA GC content, CpG frequency and methylation status, overview
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-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNA GC content, CpG frequency and methylation status, overview
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-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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-
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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-
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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-
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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-
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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both DNMT3A and DNMT3B are involved in de novo DNA methylation. 5'-Cytosine methylation is a common epigenetic modification in eukaryotic genomes
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
DNA cytosine methylation is one of the major epigenetic gene silencing marks in the human genome facilitated by DNA methyltransferases
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNA GC content, CpG frequency and methylation status, overview
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-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNA GC content, CpG frequency and methylation status, overview
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-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNA GC content, CpG frequency and methylation status, overview
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-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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-
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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both DNMT3A and DNMT3B are involved in de novo DNA methylation. 5'-Cytosine methylation is a common epigenetic modification in eukaryotic genomes
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNMT1 participates in epigenetic reprogramming through its ability to distinguish different categories of methylated sequences. Genomic imprinting is a mammalian epigenetic process that distinguishes maternal and paternal alleles to ensure parent-specific, monoallelic expression of imprinted genes. Preimplantation DNMT1-dependent maintenance mechanism specifically targets DMD sequences, e.g. of IAP, alpha-actin, Snurf/Snrpn, H19, Gnas, and Gtl2 DMD, overview
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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-
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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-
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNA GC content, CpG frequency and methylation status, overview
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-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNA GC content, CpG frequency and methylation status, overview
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-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNA GC content, CpG frequency and methylation status, overview
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-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNMT1 is crucial for cell survival
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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SinI DNA methyltransferase, a component of the SinI restriction-modification system, recognizes the sequence GG(A/T)CC and methylates the inner cytosine to produce 5-methylcytosine
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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M.SssI is the only known prokaryotic C5-MTase, which recognizes the short sequence CG and thus has the same specificity as mammalian MTases
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?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
nonselective cytosine methylation activity. Chloroplast DNA methylation by DMT1 is one of the factors influencing maternal inheritance of chloroplast genes
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?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
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?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
DNMT1 interacts with hSNF2H chromatin remodeling enzyme and binds mononucleosomes with higher affinity in the presence of hSNF2H
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?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
DNMT3B interacts with several components of the condensin complex (hCAP-C,hCAP-E and hCAP-G) and KIF4A. Condensin mediates genome-wide chromosome condensation at the onset of mitosis and is critical for proper segregation of sister chromatids. KIF4A is proposed to be a motor protein carrying DNA as cargo. DNMT3B also interacts with histone deacetylase 1 (HDAC1), the co-repressor SIN3A and the ATP-dependent chromatin remodeling enzyme hSNF2H. DNMT3B co-localizes with condensin and KIF4A on condensed chromosomes throughout mitosis, direct link between the machineries regulating DNA methylation and mitotic chromosome condensation. DNMT3B may have a previously unrecognized function during the mitotic phase of the cell cycle
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?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
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hypermethylation of CpG islands in the promoter regions is an important mechanism to silence the expression of many important genes in cancer
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?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
the enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine onto the 5'-position of the cytosine ring of the DNA
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?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
the enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine onto the 5 position of the cytosine ring of the DNA
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?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
Dnmt1 plays an essential role in the faithful and efficient maintenance of methylation patterns in the mammalian genome
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?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
major enzyme in maintenance of the pattern of DNA methylation after DNA replication
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?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
the enzyme is a de novo-type DNA methyltransferase
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?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
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NtDRM1 is a de novo cytosine methyltransferase which actively excludes CpG substrate
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?
additional information
?
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DNA fragment RPS belongs to a group of middle repetitive, dispersed and hypermethylated homologues. Repetitiveness, however, is not a prerequisite for hypermethylation, as RPS transgenes are efficient methylation targets in Arabidopsis, which lacks any significant RPS homology
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?
additional information
?
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DNA fragment RPS belongs to a group of middle repetitive, dispersed and hypermethylated homologues. Repetitiveness, however, is not a prerequisite for hypermethylation, as RPS transgenes are efficient methylation targets in Arabidopsis, which lacks any significant RPS homology
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?
additional information
?
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tRNA binding studies show that EhMeth interacts with a RNA substrate only containing 17 nucleotides of the tRNA anticodon stem-loop (including the substrate cytosine C38), but requires a full-length tRNA for stable complex formation
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?
additional information
?
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using a yeast two-hybrid screen enolase (EC 4.2.1.11) is identified as a Dnmt2-binding protein, acting as a Dnmt2 inhibitor
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?
additional information
?
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enzyme induces DNA bending, a mechanism to establish specific interface between proteins and DNA. Enzymes recognizing a cytosine 3' to the target cytosine tend to induce greater bends than enzymes with guanine in this position
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?
additional information
?
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enzyme induces DNA bending, a mechanism to establish specific interface between proteins and DNA. Enzymes recognizing a cytosine 3' to the target cytosine tend to induce greater bends than enzymes with guanine in this position
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?
additional information
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the enzyme is capable of protecting plasmid DNA in vivo against action of the cognate restriction endonuclease
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?
additional information
?
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enzyme induces DNA bending, a mechanism to establish specific interface between proteins and DNA. Enzymes recognizing a cytosine 3' to the target cytosine tend to induce greater bends than enzymes with guanine in this position
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?
additional information
?
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role of the enzyme in maintaining the methylation patterns throughout development, the enzyme may be involved in the etiology of fragile X, a syndrome characterized by de novo methylation of a greatly expanded CGG-CCG triplet repeat sequence
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additional information
?
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role of the enzyme in maintaining the methylation patterns throughout development, the enzyme may be involved in the etiology of fragile X, a syndrome characterized by de novo methylation of a greatly expanded CGG-CCG triplet repeat sequence
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?
additional information
?
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upon activation of ER-target gene expression, CpG dinucleotides of promoters undergo cyclical demethylation and remethylation with a cycle time of roughly 2 h, cyclical recruitment of DNMT3A and DNMT3B DNA methyltransferases to the promoter regions of estrogen receptoralpha target genes. In cancer cells, DNMT3A and DNMT3B might posses deaminase activity and be involved in a dynamic demethylation-methylation pathway that operates during gene transcription, overview
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?
additional information
?
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enzyme induces DNA bending, a mechanism to establish specific interface between proteins and DNA. Enzymes recognizing a cytosine 3' to the target cytosine tend to induce greater bends than enzymes with guanine in this position
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?
additional information
?
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intrinsic sequence-specificity of Dnmt1 on linear duplex DNA is unlikely to be important in the establishment of genomic methylation patterns
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?
additional information
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the enzyme is essential for viable mammalian development and has a central function in the determination and maintenance of epigenetic methalation pattern
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?
additional information
?
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enzymatic DNA methylation of carbon 5 of cytosines is an epigenetic modification that plays a role in regulating gene expression, differentiation, and tumorigenesis. DNA (cytosine-C5)-methyltransferase-1 is the enzyme responsible for maintaining established methylation patterns during replication in mammalian cells
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?
additional information
?
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interactions between Dnmt3b and both Tdg and Mbd4, i.e. G/T mismatch-specific thymine-DNA glycosylase and methyl-CpG binding domain protein 4, two thymine glycosylases involved in reduction of the impact of 5mC deamination, that can both excise uracil or thymine at U-G and T-G mismatches to initiate base excision repair, overview. Interaction with Tdg via two separate Dnmt3b domains, but MTase motif I of the catalytic domain of Dnmt3b is sufficient for interaction with Tdg and Mbd4
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?
additional information
?
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upon activation of ER? target gene expression, CpG dinucleotides of promoters undergo cyclical demethylation and remethylation with a cycle time of roughly 2 h, cyclical recruitment of DNMT3A and DNMT3B DNA methyltransferases to the promoter regions of estrogen receptoralpha target genes. In cancer cells, DNMT3A and DNMT3B might posses deaminase activity and be involved in a dynamic demethylation-methylation pathway that operates during gene transcription, overview
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?
additional information
?
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MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
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?
additional information
?
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MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
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?
additional information
?
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Q10C15
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
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?
additional information
?
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MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
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?
additional information
?
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Q8H854
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
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?
additional information
?
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MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
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?
additional information
?
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MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
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?
additional information
?
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methylation of genomic DNA is involved in the basic mechanism of gene inactivation, chromatin organization, X-chromosome inactivation, and genomic imprinting
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additional information
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the enzyme catalyzes the methylation of DNA during replication, in NGF-induced PC12 cell. The enzyme activity is sharply reduced 4 days after induction of differentiation
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additional information
?
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enzyme induces DNA bending, a mechanism to establish specific interface between proteins and DNA. Enzymes recognizing a cytosine 3' to the target cytosine tend to induce greater bends than enzymes with guanine in this position
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?
additional information
?
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enzyme induces DNA bending, a mechanism to establish specific interface between proteins and DNA. Enzymes recognizing a cytosine 3' to the target cytosine tend to induce greater bends than enzymes with guanine in this position
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