2.1.1.34: tRNA (guanosine18-2'-O)-methyltransferase
This is an abbreviated version!
For detailed information about tRNA (guanosine18-2'-O)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.34
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2.1.1.34
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thermophilus
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thermus
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d-loops
-
ribose
-
methyltransferases
-
trnaphe
-
adomet
-
2'-o-methyltransferases
-
2'-o-methylguanosine
-
analysis
-
s-adenosyl-l-homocysteine
-
medicine
-
methyl-transfer
- 2.1.1.34
- thermophilus
-
thermus
-
d-loops
- ribose
- methyltransferases
- trnaphe
- adomet
-
2'-o-methyltransferases
- 2'-o-methylguanosine
- analysis
- s-adenosyl-l-homocysteine
- medicine
-
methyl-transfer
Reaction
Synonyms
methyltransferase, transfer ribonucleate guanosine 2'-, S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase, SpoU, TARBP1, transfer ribonucleate guanosine 2'-methyltransferase, transfer RNA (Gm18) methyltransferase, TrmH, tRNA (Gm18) 2'-O-methyltransferase, tRNA (Gm18) methyltransferase, tRNA (guanosine-2'-O-)-methyltransferase, tRNA Gm18 methyltransferase, tRNA guanosine 2'-methyltransferase
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Reference
Reference on EC 2.1.1.34 - tRNA (guanosine18-2'-O)-methyltransferase
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Gefter, M.L.
The in vitro synthesis of 2-methylguanosine and 2-methylthio 6N(gamma,gamma, dimethylallyl)adenosine in transfer RNA of Escherichia coli
Biochem. Biophys. Res. Commun.
36
435-441
1969
Escherichia coli, Escherichia coli CA274
Kumagai, I.; Watanabe, K.; Oshima, T.
A thermostable tRNA (guanosine-2)-methyltransferase from Thermus thermophilus HB27 and the effect of ribose methylation on the conformational stability of tRNA
J. Biol. Chem.
257
7388-7395
1982
Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
Matsumoto, T.; Watanabe, K.; Ohta, T.
Recognition mechanism of tRNA with tRNA(guanosine-2)methyltransferase from Thermus thermophilus HB 27
Nucleic Acids Symp. Ser.
15
131-134
1984
Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
Hori, H.; Matsumoto, T.; Watanabe, K.; Ohta, T.; Miura, K.
Two types of tRNA(Gm)methylase found in extreme thermophile, Thermus thermophilus strains HB 8 and HB 27
Nucleic Acids Symp. Ser.
16
225-228
1985
Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
Matsumoto, T.; Ohta, T.; Kumagai, I.; Oshima, T.; Murao, K.; Hasegawa, T.; Ishikura, H.; Watanabe, K.
A thermostable Gm-methylase recognizes the tertiary structure of tRNA
J. Biochem.
101
1191-1198
1987
Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
Matsumoto, T.; Nishikawa, K.; Hori, H.; Ohta, T.; Miura, K.; Watanabe, K.
Recognition sites of tRNA by a thermostable tRNA(guanosine-2-)-methyltransferase from Thermus thermophilus HB27
J. Biochem.
107
331-338
1990
Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
Hori, H.; Yamazaki, N.; Matsumoto, T.; Watanabe, Y.I.; Ueda, T.; Nishikawa, K.; Kumagai, I.; Watanabe, K.
Substrate recognition of tRNA (guanosine-2'-)-methyltransferase from Thermus thermophilus HB27
J. Biol. Chem.
273
25721-25727
1998
Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
Hori, H.; Yamazaki, N.; Matsumoto, T.; Ueda, T.; Nishikawa, K.; Izumi, K.; Watanabe, K.
Essentially minimal sequence for substrate recognition by tRNA (guanosine-2')-methyltransferase from Thermus thermophilus HB27
Nucleic Acids Symp. Ser.
37
189-190
1997
Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
Hori, H.; Suzuki, T.; Sugawara, K.; Inoue, Y.; Shibata, T.; Kuramitsu, S.; Yokoyama, S.; Oshima, T.; Watanabe, K.
Identification and characterization of tRNA (Gm18) methyltransferase from Thermus thermophilus HB8: domain structure and conserved amino acid sequence motifs
Genes Cells
7
259-272
2002
Thermus thermophilus (Q9FAC4), Thermus thermophilus
Persson, B.C.; Jager, G.; Gustafsson, C.
The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2'-O-methyltransferase activity
Nucleic Acids Res.
25
4093-4097
1997
Escherichia coli
Hori, H.; Kubota, S.; Watanabe, K.; Kim, J.M.; Ogasawara, T.; Sawasaki, T.; Endo, Y.
Aquifex aeolicus tRNA (Gm18) methyltransferase has unique substrate specificity: tRNA recognition mechanism of the enzyme
J. Biol. Chem.
278
25081-25090
2003
Aquifex aeolicus (O67577), Aquifex aeolicus
Watanabe, K.; Nureki, O.; Fukai, S.; Ishii, R.; Okamoto, H.; Yokoyama, S.; Endo, Y.; Hori, H.
Roles of conserved amino acid sequence motifs in the SpoU (TrmH) RNA methyltransferase family
J. Biol. Chem.
280
10368-10377
2005
Thermus thermophilus
Nureki, O.; Watanabe, K.; Fukai, S.; Ishii, R.; Endo, Y.; Hori, H.; Yokoyama, S.
Deep knot structure for construction of active site and cofactor binding site of tRNA modification enzyme
Structure
12
593-602
2004
Thermus thermophilus (Q9FAC4)
Pleshe, E.; Truesdell, J.; Batey, R.T.
Structure of a class II TrmH tRNA-modifying enzyme from Aquifex aeolicus
Acta Crystallogr. Sect. F
61
722-728
2005
Aquifex aeolicus (O67577)
Watanabe, K.; Nureki, O.; Fukai, S.; Endo, Y.; Hori, H.
Functional categorization of the conserved basic amino acid residues in TrmH (tRNA (Gm18) methyltransferase) enzymes
J. Biol. Chem.
281
34630-34639
2006
Thermus thermophilus
Watanabe, K.; Nureki, O.; Fukai, S.; Endo, Y.; Hori, H.
Structural change of tRNA (Gm18) methyltransferase by binding of methyl donor analogues
Nucleic Acids Symp. Ser.
49
301-302
2005
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Iwashita, C.; Hori, H.
Amount changes of tRNA modification enzymes in Thermus thermophilus HB8 cells according to culture temperatures
Nucleic Acids Symp. Ser.
50
247-248
2006
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Ochi, A.; Makabe, K.; Kuwajima, K.; Hori, H.
Flexible recognition of the tRNA G18 methylation target site by TrmH methyltransferase through first binding and induced fit processes
J. Biol. Chem.
285
9018-9029
2010
Thermus thermophilus
Subramanian, M.; Srinivasan, T.; Sudarsanam, D.
Examining the Gm18 and m(1)G modification positions in tRNA sequences
Genomics Inform.
12
71-75
2014
Nitrobacter hamburgensis, Marinobacter nauticus, Marinomonas sp., Marinomonas sp. MWYL1
Ochi, A.; Makabe, K.; Yamagami, R.; Hirata, A.; Sakaguchi, R.; Hou, Y.M.; Watanabe, K.; Nureki, O.; Kuwajima, K.; Hori, H.
The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and nonsubstrate tRNA via an induced-fit process
J. Biol. Chem.
288
25562-25574
2013
Escherichia coli, Thermus thermophilus (Q9FAC4), Thermus thermophilus
Gehrig, S.; Eberle, M.E.; Botschen, F.; Rimbach, K.; Eberle, F.; Eigenbrod, T.; Kaiser, S.; Holmes, W.M.; Erdmann, V.A.; Sprinzl, M.; Bec, G.; Keith, G.; Dalpke, A.H.; Helm, M.
Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity
J. Exp. Med.
209
225-233
2012
Escherichia coli
Joeckel, S.; Nees, G.; Sommer, R.; Zhao, Y.; Cherkasov, D.; Hori, H.; Ehm, G.; Schnare, M.; Nain, M.; Kaufmann, A.; Bauer, S.
The 2-O-methylation status of a single guanosine controls transfer RNA-mediated Toll-like receptor 7 activation or inhibition
J. Exp. Med.
209
235-241
2012
Escherichia coli, Thermus thermophilus
Hori, H.; Terui, Y.; Nakamoto, C.; Iwashita, C.; Ochi, A.; Watanabe, K.; Oshima, T.
Effects of polyamines from Thermus thermophilus, an extreme-thermophilic eubacterium, on tRNA methylation by tRNA (Gm18) methyltransferase (TrmH)
J. Biochem.
159
509-517
2016
Thermus thermophilus (Q5SM16), Thermus thermophilus, Thermus thermophilus DSM 579 (Q5SM16)
Freund, I.; Buhl, D.K.; Boutin, S.; Kotter, A.; Pichot, F.; Marchand, V.; Vierbuchen, T.; Heine, H.; Motorin, Y.; Helm, M.; Dalpke, A.H.; Eigenbrod, T.
2-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms
RNA
25
869-880
2019
Saccharomyces cerevisiae, Escherichia coli, Homo sapiens (Q13395), Homo sapiens, Escherichia coli BW25113
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