2.1.1.33: tRNA (guanine46-N7)-methyltransferase
This is an abbreviated version!
For detailed information about tRNA (guanine46-N7)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.33
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2.1.1.33
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methyltransferase-like
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n7-methylguanosine
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cyp27b1
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mettl21b
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trnaphe
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mescs
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kidney-specific
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methylome
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submodules
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methyl-transfer
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pharmacology
- 2.1.1.33
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methyltransferase-like
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n7-methylguanosine
- cyp27b1
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mettl21b
- trnaphe
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mescs
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kidney-specific
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methylome
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submodules
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methyl-transfer
- pharmacology
Reaction
Synonyms
7-methylguanine transfer ribonucleate methylase, m7G-methyltransferase, m7G46 methyltransferase Trm8p/Trm82p, methyltransferase like 1, methyltransferase, transfer ribonucleate guanine 7-, METTL1, N7-methylguanine methylase, PA14_05000, transfer ribonucleate guanine 7-methyltransferase, transfer RNA (m7G46) methyltransferase, Trm8–Trm82 complex, TrmB, TrMet (m7G46), tRNA (m7G46) methyltransferase, tRNA guanine 7-methyltransferase
ECTree
2.1.1.33 tRNA (guanine46-N7)-methyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.1.1.33 - tRNA (guanine46-N7)-methyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + guanine46 in methyl deficient tRNA from E. coli
?
-
-
-
-
?
S-adenosyl-L-methionine + guanine46 in RNAAla/UGC
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAAla/UGC
S-adenosyl-L-methionine + guanine46 in RNAArg/ACG
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/ACG
S-adenosyl-L-methionine + guanine46 in RNAArg/CCG
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/CCG
S-adenosyl-L-methionine + guanine46 in RNAArg/CCU
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/CCU
S-adenosyl-L-methionine + guanine46 in RNAArg/UCU
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/UCU
-
-
-
?
S-adenosyl-L-methionine + guanine46 in RNAAsn/GUU
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAAsn/GUU
-
-
-
?
S-adenosyl-L-methionine + guanine46 in RNAAsp/GUC
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAAsp/GUC
-
-
-
?
S-adenosyl-L-methionine + guanine46 in RNAGly/GCC
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAGly/GCC
-
-
-
?
S-adenosyl-L-methionine + guanine46 in RNAHis/GUG
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAHis/GUG
-
-
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?
S-adenosyl-L-methionine + guanine46 in RNAIle/GAU
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAIle/GAU
-
-
-
?
S-adenosyl-L-methionine + guanine46 in RNALys/UUU
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNALys/UUU
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-
-
?
S-adenosyl-L-methionine + guanine46 in RNAThr/CGU
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAThr/CGU
-
-
-
?
S-adenosyl-L-methionine + guanine46 in RNAVal/GAC
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAVal/GAC
-
-
-
?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
S-adenosyl-L-methionine + guanine46 in tRNAAla/GGC
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAAla/GGC
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-
-
?
S-adenosyl-L-methionine + guanine46 in tRNAMet/CAU
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAMet/CAU
-
-
-
?
S-adenosyl-L-methionine + guanine46 in tRNAPhe
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAPhe
substrate tRNAPhe of Saccharomyces cerevisiae
-
-
?
S-adenosyl-L-methionine + guanine46 in tRNAPhe/GAA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAPhe/GAA
-
-
-
?
S-adenosyl-L-methionine + guanine46 in tRNAPro/CGG
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAPro/CGG
-
-
-
?
S-adenosyl-L-methionine + guanine46 in tRNAPro/GGG
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAPro/GGG
-
-
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?
S-adenosyl-L-methionine + guanine46 in tRNAPro/UGG
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAPro/UGG
-
-
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?
S-adenosyl-L-methionine + guanine46 in tRNAThr/GGU
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAThr/GGU
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-
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?
S-adenosyl-L-methionine + guanine46 in tRNAThr/UGU
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAThr/UGU
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-
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?
S-adenosyl-L-methionine + guanine46 in tRNATrp/CCA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNATrp/CCA
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-
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?
S-adenosyl-L-methionine + guanine46 in tRNAVal/UAC
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNAVal/UAC
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-
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?
S-adenosyl-L-methionine + guanine46 in undermethylated tRNA
?
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-
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?
S-adenosyl-L-methionine + guanine46 in RNAAla/UGC
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAAla/UGC
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-
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?
S-adenosyl-L-methionine + guanine46 in RNAAla/UGC
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAAla/UGC
-
-
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?
S-adenosyl-L-methionine + guanine46 in RNAArg/ACG
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/ACG
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-
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?
S-adenosyl-L-methionine + guanine46 in RNAArg/ACG
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/ACG
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-
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?
S-adenosyl-L-methionine + guanine46 in RNAArg/CCG
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/CCG
-
-
-
?
S-adenosyl-L-methionine + guanine46 in RNAArg/CCG
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/CCG
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-
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?
S-adenosyl-L-methionine + guanine46 in RNAArg/CCU
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/CCU
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-
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?
S-adenosyl-L-methionine + guanine46 in RNAArg/CCU
S-adenosyl-L-homocysteine + N7-methylguanine46 in RNAArg/CCU
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-
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?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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-
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?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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-
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?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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methyl group acceptor: methyl-deficient tRNA from E. coli
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?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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methyl group acceptor: methyl-deficient tRNA from E. coli
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ir
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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highly specific for tRNA and S-adenosyl-L-methionine, cannot be replaced by methionine plus ATP, formaldehyde plus tetrahydrofolic acid, methylcobalamin and methyltetrahydrofolic acid
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ir
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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methyl group acceptors: methyl-deficient bulk tRNA from E. coli K12met-rel-, tRNAfMet from Bacillus subtilis, formation of 0.8 mol N7-methylguanine residues per mol Bacillus subtilis tRNA, enzyme recognizes and methylates specifically the extra arm unpaired methyl-deficient guanylate residue
-
?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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extend of methylation is directly proportional to the amount of tRNA added, 0.19% of nucleotide residues are methylated
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ir
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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methyl group acceptors: methyl-deficient bulk tRNA from E. coli K12met-rel-, tRNAfMet from Bacillus subtilis, formation of 0.8 mol N7-methylguanine residues per mol Bacillus subtilis tRNA, enzyme recognizes and methylates specifically the extra arm unpaired methyl-deficient guanylate residue
-
?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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methyl group acceptor: yeast pre-tRNAPhe
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-
?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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methyl group acceptor: yeast tRNA1Ala, methylates G located in the extra loop at position 46 from the 5Â’ end of tRNA1Ala
-
?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
-
methyl group acceptor: yeast tRNA1Ala, methylates G located in the extra loop at position 46 from the 5Â’ end of tRNA1Ala
-
?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
-
-
-
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?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
Q03774; Q12009
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-
-
?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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methyl group acceptor: methyl-deficient tRNA from E. coli
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?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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methyl group acceptors: tRNACys, tRNATrp, tRNAPro, tRNAMet, tRNAMet-i and 2 of each tRNAPhe, tRNAVal and tRNALys, methylation at G46 in the extra loop
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?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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methyl group acceptor: yeast pre-tRNAPhe
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?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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complex of 2 proteins Trm8 and Trm82 is required for efficient m7G-methyltransferase activity in vitro and in vivo, tRNA site G46 is methylated in vivo
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?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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methyl group acceptor: methyl-deficient tRNA from E. coli
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?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
-
-
-
-
?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
-
methyl group acceptor: undermethylated tRNA
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?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
-
methyl group acceptor: undermethylated tRNA from Salmonella typhimurium CS 14, NH2- and COOH-group of S-adenosyl-L-methionine as well as the length of hydrocarbon chain connecting them to the aromatic ring of adenosine, chirality at the alpha-C atom and NH2-group of adenosine are important for substrate binding to enzyme
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?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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tRNA modifying enzyme
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?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
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specific enzyme involved in the maturation of tRNA
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?
S-adenosyl-L-methionine + guanine46 in tRNA
S-adenosyl-L-homocysteine + N7-methylguanine46 in tRNA
-
-
-
-
?
additional information
?
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no substrates: tRNALeu/CAG, tRNALeu/GAG, and tRNASec(p)/UCA
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-
-
additional information
?
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no substrates: tRNALeu/CAG, tRNALeu/GAG, and tRNASec(p)/UCA
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-
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additional information
additional information
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not as methyl group acceptors: methyl-deficient DNA from E. coli, polyadenylic acid, polycytidylic acid, polyuridylic acid, polyinosinic acid, copolymers of adenylic acid and uridylic acid and of guanylic acid and cytidylic acid, tobacco mosaic viral RNA, turnip yellow mosaic viral RNA, RNA from bacteriophage f2, CMP, AMP, UMP, GMP, rRNA
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-
?
additional information
additional information
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methyl group transfer at the polynucleotide level of tRNA, two m7G tRNA-methyltransferases with different specificities for the extra arm unpaired G in different tRNA species
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-
?
additional information
additional information
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methyl group transfer at the polynucleotide level of tRNA, two m7G tRNA-methyltransferases with different specificities for the extra arm unpaired G in different tRNA species
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-
?
additional information
additional information
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-
proteins METTL1 and WDR4 are required for m7G-methyltransferase activity
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-
?
additional information
additional information
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complex of 2 proteins Trm8 and Trm82 is required for efficient m7G-methyltransferase activity in vitro and in vivo, but Trm82 is not an absolute requirement for activity in vitro, Trm8 may be the catalytically active subunit
-
-
?
