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2.1.1.321: type III protein arginine methyltransferase

This is an abbreviated version!
For detailed information about type III protein arginine methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.321

Reaction

S-adenosyl-L-methionine
+
[protein]-L-arginine
=
S-adenosyl-L-homocysteine
 +
[protein]-Nomega-methyl-L-arginine

Synonyms

EC 2.1.1.124, EC 2.1.1.125, EC 2.1.1.126, EC 2.1.1.23, PRMT-7, PRMT7, protein arginine methyltransferase 7

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.321 type III protein arginine methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.321 - type III protein arginine methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + [protein]-L-arginine
2 S-adenosyl-L-homocysteine + [protein]-Nomega-dimethyl-L-arginine
show the reaction diagram
3 S-adenosyl-L-methionine + SGRGKGGKGLGKGGAKRHRK-NH2
3 S-adenosyl-L-homocysteine + SG-(Nomega-Me)RGKGGKGLGKGGAK-(Nomega-Me)RH-(Nomega-Me)RK-NH2
show the reaction diagram
-
-
-
?
5 S-adenosyl-L-methionine + AGRGRGKAAILKAQVAARGRGRGMGRGN-NH2
5 S-adenosyl-L-homocysteine + AG-(Nomega-Me)RG-(Nomega-Me)RGKAAILKAQVAA-(Nomega-Me)RG-(Nomega-Me)RGRGMG-(Nomega-Me)RGN-NH2
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + acetyl-GGRGG-NH2
S-adenosyl-L-homocysteine + acetyl-GG-(Nomega-methyl-)RGG-NH2
show the reaction diagram
substrate is a synthetic peptide
-
-
?
S-adenosyl-L-methionine + GGFGGRGGFG-NH2
S-adenosyl-L-homocysteine + GGFGG-(Nomega-methyl-)RGGFG-NH2
show the reaction diagram
substrate is a synthetic peptide
product is monomethylated at residue R6
-
?
S-adenosyl-L-methionine + GGPGGRGGPGG-NH2
S-adenosyl-L-homocysteine + GGPGG-Nomega-methyl-RGGPGG
show the reaction diagram
substrate is a synthetic peptide
enzyme catalyzes monomethylation of Arg-residues
-
?
S-adenosyl-L-methionine + SG-(Nomega-methyl-)RGKGGKGLGKGGAKRHRK-NH2
S-adenosyl-L-homocysteine + SG-(Nomega-methyl-)RGKGGKGLGKGGAK-(Nomega-methyl-)RHRK-NH2
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [Ac-GGRGGFGGKGGCGGKGGFGGKGGFG peptide]-L-arginine
S-adenosyl-L-homocysteine + [Ac-GGRGGFGGKGGCGGKGGFGGKGGFG peptide]-Nomega-methyl-L-arginine
show the reaction diagram
S-adenosyl-L-methionine + [beta-catenin]-L-arginine
S-adenosyl-L-homocysteine + [beta-catenin]-Nomega-methyl-L-arginine
show the reaction diagram
S-adenosyl-L-methionine + [eukaryotic translation initiation factor 2alpha]-L-arginine
S-adenosyl-L-homocysteine + [eukaryotic translation initiation factor 2alpha]-Nomega-methyl-L-arginine
show the reaction diagram
S-adenosyl-L-methionine + [GLI2]-L-arginine
S-adenosyl-L-homocysteine + [GLI2]-Nomega-methyl-L-arginine
show the reaction diagram
PRMT7 interacts with and methylates GLI2 on arginine residues 225 and 227 nearby a binding region of SUFU, a negative regulator of GLI2
-
-
?
S-adenosyl-L-methionine + [GST-GAR]-L-arginine
S-adenosyl-L-homocysteine + [GST-GAR]-Nomega-methyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [histone H2A]-L-arginine
S-adenosyl-L-homocysteine + [histone H2A]-Nomega-methyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [histone H2B peptide 23-37]-L-arginine
S-adenosyl-L-homocysteine + [histone H2B peptide 23-37]-Nomega-methyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [histone H2B]-L-arginine
S-adenosyl-L-homocysteine + [histone H2B]-Nomega-methyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [histone H3]-L-arginine
S-adenosyl-L-homocysteine + [histone H3]-Nomega-methyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [histone H4 peptide 1-20]-L-arginine
S-adenosyl-L-homocysteine + [histone H4 peptide 1-20]-Nomega-methyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [histone H4 peptide 14-22]-L-arginine
S-adenosyl-L-homocysteine + [histone H4 peptide 14-22]-Nomega-methyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [histone H4R17]-L-arginine
S-adenosyl-L-homocysteine + [histone H4R17]-Nomega-methyl-L-arginine
show the reaction diagram
S-adenosyl-L-methionine + [histone H4R3]-L-arginine
S-adenosyl-L-homocysteine + [histone H4R3]-Nomega-dimethyl-L-arginine
show the reaction diagram
S-adenosyl-L-methionine + [human histone H2B peptide]-L-arginine
S-adenosyl-L-homocysteine + [human histone H2B peptide]-Nomega-methyl-L-arginine
show the reaction diagram
Caenorhabditis elegans PRMT-7 is able to methylate synthetic human histone H2B peptides containing residues 23-37. The C. elegans enzyme recognizes the human peptide better than the Caenorhabditis elegans peptide. The histone H2B R29K peptide reduces methylation counts to a level about 40%, of that of the wild type peptide sequence. The R31K and R33K mutant peptides further decrease the activity to about 10% and 22% respectively, signifying the importance of arginine residues in a sequential R-X-R motif
-
-
?
S-adenosyl-L-methionine + [myelin basic protein]-L-arginine
S-adenosyl-L-homocysteine + [myelin basic protein]-Nomega-methyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [protein]-L-arginine
S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine
show the reaction diagram
S-adenosyl-L-methionine + [Smb protein]-L-arginine
S-adenosyl-L-homocysteine + [Smb protein]-Nomega-methyl-L-arginine
show the reaction diagram
-
-
-
?
additional information
?
-