2.1.1.321: type III protein arginine methyltransferase

This is an abbreviated version!
For detailed information about type III protein arginine methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.321

2.1.1.321

prmt7

histone

monomethylation

metastasis

monomethylarginine

dimethylarginine

nanog

adomet

medicine

Reaction

Synonyms

EC 2.1.1.124, EC 2.1.1.125, EC 2.1.1.126, EC 2.1.1.23, PRMT-7, PRMT7, protein arginine methyltransferase 7

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.321 type III protein arginine methyltransferase

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Results	in table
1008	AA Sequence
1	Application
4	Cloned(Commentary)
3	Crystallization (Commentary)
24	Disease/ Diagnostics
1	Expression
21	General Information
2	Inhibitors
1	kcat/KM [mM/s]
1	KM Value [mM]
2	Localization
1	Metals/Ions
3	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
26	Organism
1	PDB ID
8	Protein Variants
3	Purification (Commentary)
1	Reaction
24	Reference
27	Source Tissue
37	Substrates and Products (Substrate)
2	Subunits
27	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Temperature Range [°C]
1	Turnover Number [1/s]

Engineering

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Engineering on EC 2.1.1.321 - type III protein arginine methyltransferase

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F71A

Trypanosoma brucei brucei

Q582G4

the mutant preserves the type III (mono)methyltransferase behavior of the native enzyme

757304

F71I

Trypanosoma brucei brucei

Q582G4

the mutation of Phe71 to Ile converts the enzyme from a type III (mono)methyltransferase into a mixed type I/II, that is, an enzyme that can now perform dimethylation

757304

F71S

Trypanosoma brucei brucei

Q582G4

the mutant preserves the type III (mono)methyltransferase behavior of the native enzyme

757304

F71A

Trypanosoma brucei brucei 927

the mutant preserves the type III (mono)methyltransferase behavior of the native enzyme

F71I

Trypanosoma brucei brucei 927

the mutation of Phe71 to Ile converts the enzyme from a type III (mono)methyltransferase into a mixed type I/II, that is, an enzyme that can now perform dimethylation

F71S

Trypanosoma brucei brucei 927

the mutant preserves the type III (mono)methyltransferase behavior of the native enzyme

additional information

3 entries