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2.1.1.321: type III protein arginine methyltransferase

This is an abbreviated version!
For detailed information about type III protein arginine methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.321

Reaction

S-adenosyl-L-methionine
+
[protein]-L-arginine
=
S-adenosyl-L-homocysteine
+
[protein]-Nomega-methyl-L-arginine

Synonyms

EC 2.1.1.124, EC 2.1.1.125, EC 2.1.1.126, EC 2.1.1.23, PRMT-7, PRMT7, protein arginine methyltransferase 7

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.321 type III protein arginine methyltransferase

Application

Application on EC 2.1.1.321 - type III protein arginine methyltransferase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
isoform PRMT7 expression is significantly upregulated in both primary breast tumour tissues and in breast cancer lymph node metastases. Reducing PRMT7 levels in invasive breast cancer cells using RNA interference significantly decreases cell invasion in vitro and metastasis in vivo. Overexpression of PRMT7 in non-aggressive MCF-7 cells enhances their invasiveness. PRMT7 induces the expression of matrix metalloproteinase MMP9. Invasion of aggressive breast cancer cells depleted of PRMT7 may be rescued by the exogenous expression of MMP9