2.1.1.311: 25S rRNA (cytosine2278-C5)-methyltransferase
This is an abbreviated version!
For detailed information about 25S rRNA (cytosine2278-C5)-methyltransferase, go to the full flat file.
Reaction
Synonyms
RCM1, ribosomal RNA cytosine methyltransferase 1, YNL022C
ECTree
2.1.1.311 25S rRNA (cytosine2278-C5)-methyltransferaseAdvanced search results
results (
results (| Results | in table |
|---|---|
| 8 | AA Sequence |
| 2 | Expression |
| 6 | General Information |
| 6 | Natural Substrates/ Products (Substrates) |
| 12 | Organism |
| 1 | Reaction |
| 6 | Reference |
| 12 | Substrates and Products (Substrate) |
| 10 | Synonyms |
| 1 | Systematic Name |
General Information
General Information on EC 2.1.1.311 - 25S rRNA (cytosine2278-C5)-methyltransferase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
malfunction
physiological function
malfunction
deletion of Rcm1 specifically abolishes the methylation of m5C 2278 in the 25S rRNA. The loss of m5C2278 results in anisomycin hypersensitivity. The deletion of rcm1 does not result in any significant growth defect at 30 and 37°C. Deletion of rcm1 does not disturb the 60S stoichiometry and polysome assembly
malfunction
loss of Rcm1 alters the structural conformation of the ribosome in close proximity to C2278, as well as translational fidelity, and favours recruitment of a distinct subset of oxidative stress-responsive mRNAs into polysomes
malfunction
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loss of Rcm1 alters the structural conformation of the ribosome in close proximity to C2278, as well as translational fidelity, and favours recruitment of a distinct subset of oxidative stress-responsive mRNAs into polysomes
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malfunction
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deletion of Rcm1 specifically abolishes the methylation of m5C 2278 in the 25S rRNA. The loss of m5C2278 results in anisomycin hypersensitivity. The deletion of rcm1 does not result in any significant growth defect at 30 and 37°C. Deletion of rcm1 does not disturb the 60S stoichiometry and polysome assembly
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physiological function
the methylated residues m5C2278 stabilizes the structure of 25S rRNA and consequently the association of ribosomal proteins with the large ribosomal subunit
physiological function
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the methylated residues m5C2278 stabilizes the structure of 25S rRNA and consequently the association of ribosomal proteins with the large ribosomal subunit
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