2.1.1.310: 25S rRNA (cytosine2870-C5)-methyltransferase

This is an abbreviated version!
For detailed information about 25S rRNA (cytosine2870-C5)-methyltransferase, go to the full flat file.

Reaction

Synonyms

m5C-methyltransferase, NOP2, NSUN1/Nol1, p120, proliferation-associated nucleolar antigen, protein p120, RNA:m5C-MTase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.310 25S rRNA (cytosine2870-C5)-methyltransferase

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Results	in table
11	AA Sequence
1	Application
2	Cloned(Commentary)
2	Cofactor
93	Disease/ Diagnostics
14	General Information
4	Localization
8	Natural Substrates/ Products (Substrates)
30	Organism
8	PDB ID
5	Protein Variants
1	Purification (Commentary)
3	Reaction
5	Reference
1	Source Tissue
12	Substrates and Products (Substrate)
3	Subunits
15	Synonyms
1	Systematic Name

Natural Substrates Products

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Natural Substrates Products on EC 2.1.1.310 - 25S rRNA (cytosine2870-C5)-methyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + cytosine2870 in 25S rRNA

S-adenosyl-L-homocysteine + 5-methylcytosine2870 in 25S rRNA

5 entries

additional information

?

-

3 entries

S-adenosyl-L-methionine + cytosine2870 in 25S rRNA

S-adenosyl-L-homocysteine + 5-methylcytosine2870 in 25S rRNA

Homo sapiens

-

-

737084

-

-

?

S-adenosyl-L-methionine + cytosine2870 in 25S rRNA

S-adenosyl-L-homocysteine + 5-methylcytosine2870 in 25S rRNA

Saccharomyces cerevisiae

P40991

the enzyme is responsible for the methylation at cytosine2870 of the 25S ribosomal RNA

730499

-

-

?

S-adenosyl-L-methionine + cytosine2870 in 25S rRNA

S-adenosyl-L-homocysteine + 5-methylcytosine2870 in 25S rRNA

Saccharomyces cerevisiae

-

yeast proteins Nop2p and Rcm1p catalyze the formation of m5C in domains V and IV, respectively

737084

-

-

?

S-adenosyl-L-methionine + cytosine2870 in 25S rRNA

S-adenosyl-L-homocysteine + 5-methylcytosine2870 in 25S rRNA

Saccharomyces cerevisiae ATCC 204508

P40991

the enzyme is responsible for the methylation at cytosine2870 of the 25S ribosomal RNA

730499

-

-

?

S-adenosyl-L-methionine + cytosine2870 in 25S rRNA

S-adenosyl-L-homocysteine + 5-methylcytosine2870 in 25S rRNA

Saccharomyces cerevisiae BY4742

-

yeast proteins Nop2p and Rcm1p catalyze the formation of m5C in domains V and IV, respectively

737084

-

-

?

additional information

?

-

Homo sapiens

-

protein p120 displays an RNA:m5C-MTase activity, which restores m5C formation at position 2870 in domain V of 25S rRNA in a nop2DELTA yeast strain, functional complementation of Nop2-deficient yeasts by human protein p120

737084

-

-

?

additional information

?

-

Saccharomyces cerevisiae

-

no evidence of m5C residues in yeast 18S rRNA

737084

-

-

?

additional information

?

-

Saccharomyces cerevisiae BY4742

-

no evidence of m5C residues in yeast 18S rRNA

737084

-

-

?