2.1.1.310: 25S rRNA (cytosine2870-C5)-methyltransferase
This is an abbreviated version!
For detailed information about 25S rRNA (cytosine2870-C5)-methyltransferase, go to the full flat file.
Reaction
Synonyms
m5C-methyltransferase, NOP2, NSUN1/Nol1, p120, proliferation-associated nucleolar antigen, protein p120, RNA:m5C-MTase
ECTree
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General Information
General Information on EC 2.1.1.310 - 25S rRNA (cytosine2870-C5)-methyltransferase
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evolution
malfunction
metabolism
physiological function
additional information
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the enzyme is a member of a protein family called Nop2/NSUN/NOL1. Nop2 belongs to the large family of pre-ribosomal proteins
evolution
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the enzyme is a member of a protein family called Nop2/NSUN/NOL1. The human genome contains at least 9 genes encoding putative RNA:m5C-MTases which share sequence similarities with yeast Nop2/Trm4/Rcm1
evolution
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the enzyme is a member of a protein family called Nop2/NSUN/NOL1. Nop2 belongs to the large family of pre-ribosomal proteins
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the loss of m5C2870 affects ribosome synthesis and processing
malfunction
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strains expressing Nop2DELTA(1-220) are viable, but exhibit a significant growth defect
malfunction
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strains expressing Nop2DELTA(1-220) are viable, but exhibit a significant growth defect
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malfunction
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the loss of m5C2870 affects ribosome synthesis and processing
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Nop2 and Rcm1 catalyze m5C formation in large subunit yeast rRNA, Nop2 forms 25S rRNA m5C2870, while Rcm1 forms 25S rRNA m5C2278
metabolism
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Nop2 and Rcm1 catalyze m5C formation in large subunit yeast rRNA, Nop2 forms 25S rRNA m5C2870, while Rcm1 forms 25S rRNA m5C2278
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nucleolar protein Nop2 is required for production of 25S rRNA and, consequently, during the biogenesis of 60S ribosomal subunits. Nop2 forms 25S rRNA m5C2870. the enzyme possesses two related functions in pre-rRNA processing: as an essential factor for cleavages and m5C:RNA:modification. The presence of Nop2, rather than the m5C modification in rRNA itself, is required for pre-rRNA processing
physiological function
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p120 forms 28S rRNA m5C4447. It is required for the G1/S transition
physiological function
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nucleolar protein Nop2 is required for production of 25S rRNA and, consequently, during the biogenesis of 60S ribosomal subunits. Nop2 forms 25S rRNA m5C2870. the enzyme possesses two related functions in pre-rRNA processing: as an essential factor for cleavages and m5C:RNA:modification. The presence of Nop2, rather than the m5C modification in rRNA itself, is required for pre-rRNA processing
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importance of different sequence and structural domains of Nop2 and p120 for yeast growth and m5C-MTase activity, importance of Nop2 N-terminal domain for correct protein localization and its cellular function, overview
additional information
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importance of different sequence and structural domains of Nop2 and p120 for yeast growth and m5C-MTase activity, importance of Nop2 N-terminal domain for correct protein localization and its cellular function, overview
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