2.1.1.308: cytidylyl-2-hydroxyethylphosphonate methyltransferase
This is an abbreviated version!
For detailed information about cytidylyl-2-hydroxyethylphosphonate methyltransferase, go to the full flat file.
Reaction
2 S-adenosyl-L-methionine
+
Synonyms
(S)-2-hydroxyethylphosphonate methylase, 2-hydroxyethylphosphonate methyltransferase, fom3, methyltransferase fom3
ECTree
2.1.1.308 cytidylyl-2-hydroxyethylphosphonate methyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.1.1.308 - cytidylyl-2-hydroxyethylphosphonate methyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin
(S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin
S-adenosyl-L-methionine + methylcob(III)alamin + 2-hydroxyethylphosphonate
5'-deoxyadenosine + L-methionine + cob(III)alamin + (2S)-2-hydroxypropylphosphonate
(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin
(S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin
Fom3 catalyzes the penultimate step in the biosynthesis of fosfomycin, an antibiotic produced by several species of Streptomyces and Pseudomonas
-
-
?
(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin
(S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin
the enzyme is required for fosfomycin production
-
-
?
(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin
(S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin
(S)- and (R)-(2-hydroxy[1-2H1]ethyl)phosphonic acids are fed to Streptomyces fradiae. The deuterium of (R)-(2-hydroxy[1-2H1]ethyl)phosphonic acid is lost, and the deuterium of (S)-(2-hydroxy[1-2H1]ethyl)phosphonic acid is retained on incorporation into fosfomycin
-
-
?
(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin
(S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin
C-2 methylation of hydroxyethyl phosphonate
-
-
?
(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin
(S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin
incorporation of 18O in the alcohol function of 18O-labeled HEP into the FM molecule but not of 18O2 gas
-
-
?
(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin
(S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin
no activity with (R)-2-hydroxyethylphosphonate
-
-
?
(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin
(S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin
when (R)- and (S)-2-hydroxyethylphosphonate are fed to Streptomyces fradiae producing fosfomycin, only (S)-2-hydroxyethylphosphonate is efficiently incorporated into fosfomycin (37% deuterium at C-1 of the aminophosphonic acid)
-
-
?
(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin
(S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin
-
-
-
?
S-adenosyl-L-methionine + methylcob(III)alamin + 2-hydroxyethylphosphonate
5'-deoxyadenosine + L-methionine + cob(III)alamin + (2S)-2-hydroxypropylphosphonate
-
-
-
?
S-adenosyl-L-methionine + methylcob(III)alamin + 2-hydroxyethylphosphonate
5'-deoxyadenosine + L-methionine + cob(III)alamin + (2S)-2-hydroxypropylphosphonate
the enzyme is involved in the biosynthesis of the broad-spectrum antibiotic fosfomycin
-
-
?
