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2.1.1.308: cytidylyl-2-hydroxyethylphosphonate methyltransferase

This is an abbreviated version!
For detailed information about cytidylyl-2-hydroxyethylphosphonate methyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate}
+
reduced acceptor
=
S-adenosyl-L-homocysteine
 +
5'-deoxyadenosine
 +
L-methionine
 +
cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate}
 +
oxidized acceptor

Synonyms

(S)-2-hydroxyethylphosphonate methylase, 2-hydroxyethylphosphonate methyltransferase, fom3, methyltransferase fom3

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.308 cytidylyl-2-hydroxyethylphosphonate methyltransferase

Engineering

Engineering on EC 2.1.1.308 - cytidylyl-2-hydroxyethylphosphonate methyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C282A
the mutant enzyme is not able to produce the catalytic [4Fe-4S]+1 cluster
C282A/C286A/C289A
the triple-variant is very unstable and precipitated during purification and subsequent manipulation for experiments. It completely lacks the [4Fe-4S]+1 cluster
C286A
the mutant enzyme is not able to produce the catalytic [4Fe-4S]+1 cluster
C289A
the mutant enzyme is not able to produce the catalytic [4Fe-4S]+1 cluster
additional information