2.1.1.303: 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase

This is an abbreviated version!
For detailed information about 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase, go to the full flat file.

Reaction

2-hydroxy-7-methoxy-5-methyl-1-naphthoate

Synonyms

NcsB1

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.303 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase

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Results	in table
1	Activating Compound
4	AA Sequence
2	Cloned(Commentary)
1	Crystallization (Commentary)
2	General Information
3	Inhibitors
9	kcat/KM [mM/s]
9	KM Value [mM]
2	Metals/Ions
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
2	Organism
3	Pathway
2	pH Optimum
1	pH Range
4	Protein Variants
2	Purification (Commentary)
1	Reaction
2	Reference
8	Substrates and Products (Substrate)
1	Subunits
2	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
9	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.1.1.303 - 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase

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S-adenosyl-L-methionine + 1,4-dihydroxy-2-naphthoic acid

S-adenosyl-L-homocysteine + 1-hydroxy-4-methoxy-2-naphthoate

Streptomyces carzinostaticus

Q84HC8

kcat/KM is 10% compared to the wild-type value

725380

S-adenosyl-L-methionine + 2,7-dihydroxy-5-methyl-1-naphthoate

S-adenosyl-L-homocysteine + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate

2 entries

S-adenosyl-L-methionine + 3,5-dihydroxy-2-naphthoate

S-adenosyl-L-homocysteine + 3-hydroxy-5-methoxy-2-naphthoate

Streptomyces carzinostaticus

Q84HC8

kcat/KM is 23% compared to the wild-type value

725380

S-adenosyl-L-methionine + 3,7-dihydroxy-2-naphthoate

S-adenosyl-L-homocysteine + 3-hydroxy-7-methoxy-2-naphthoate

Streptomyces carzinostaticus

Q84HC8

kcat/KM is 14% compared to the wild-type value

725380

additional information

Streptomyces carzinostaticus

Q84HC8

NcsB1 also recognizes other dihydroxynaphthoic acids as substrates and catalyzes regiospecific O-methylation. The carboxylate and its ortho-hydroxy groups of the substrate appear to be crucial for NcsB1 substrate recognition and binding, and O-methylation takes place only at the free hydroxy group of these dihydroxynaphthoic acids

725380