2.1.1.301: cypemycin N-terminal methyltransferase
This is an abbreviated version!
For detailed information about cypemycin N-terminal methyltransferase, go to the full flat file.
Reaction
2 S-adenosyl-L-methionine + = 2 S-adenosyl-L-homocysteine +
Synonyms
alpha-N-methyltransferase, CypM, S-adenosyl methionine-dependent methyltransferase
ECTree
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Systematic Name
Systematic Name on EC 2.1.1.301 - cypemycin N-terminal methyltransferase
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S-adenosyl-L-methionine:N-terminal L-alanine-[cypemycin] N-methyltransferase
The enzyme, isolated from the bacterium Streptomyces sp. OH-4156, can methylate a variety of linear oligopeptides, cyclic peptides such as nisin and haloduracin, and the epsilon-amino group of lysine [2]. Cypemycin is a peptide antibiotic, a member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides.