2.1.1.292: carminomycin 4-O-methyltransferase

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For detailed information about carminomycin 4-O-methyltransferase, go to the full flat file.

Reaction

Synonyms

4-O-methyltransferase, anthracycline 4-O-methyltransferase, anthracycline methyltransferase, carminomycin 4-OMT, class I methyltransferase, COMT, DauK, DnrK

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.292 carminomycin 4-O-methyltransferase

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Results	in table
5	AA Sequence
1	Application
7	Cloned(Commentary)
4	Cofactor
2	Crystallization (Commentary)
10	General Information
3	Inhibitors
3	kcat/KM [mM/s]
6	KM Value [mM]
1	Metals/Ions
3	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
11	Organism
5	Pathway
57	PDB ID
3	pH Optimum
1	pH Range
6	Protein Variants
3	Purification (Commentary)
1	Reaction
11	Reference
2	Source Tissue
1	Specific Activity [micromol/min/mg]
24	Substrates and Products (Substrate)
3	Subunits
18	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.1.1.292 - carminomycin 4-O-methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:carminomycin 4-O-methyltransferase

The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius are involved in the biosynthesis of the anthracycline daunorubicin. In vitro the enzyme from Streptomyces sp. C5 also catalyses the 4-O-methylation of 13-dihydrocarminomycin, rhodomycin D and 10-carboxy-13-deoxycarminomycin [3].