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2.1.1.28: phenylethanolamine N-methyltransferase

This is an abbreviated version!
For detailed information about phenylethanolamine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.28

Reaction

S-adenosyl-L-methionine
+
phenylethanolamine
=
S-adenosyl-L-homocysteine
 +
N-Methylphenylethanolamine

Synonyms

hPNMT, methyltransferase, noradrenaline N-, NMT, noradrenalin methyltransferase, noradrenalin N-methyltransferase, noradrenaline N-methyltransferase, norepinephrin N-methyltransferase, norepinephrine methyltransferase, norepinephrine N-methyltransferase, phenethanolamine methyltransferase, phenethanolamine N-methyltransferase, PNMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.28 phenylethanolamine N-methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.28 - phenylethanolamine N-methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-hydroxyphenylethanolamine + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
-
i.e. o-octopamine
-
-
?
3,4-dichlorophenyl ethanolamine + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
3,4-dichlorophenylethanolamine + S-adenosyl-L-methionine
N-methyl-3,4-dichlorophenylethanolamine + S-adenosyl-L-homocysteine
show the reaction diagram
3,4-dichlorophenylethylenediamine + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
3,4-dihydroxynorephedrine + S-adenosyl-L-methionine
3,4-dihydroxyephedrine + S-adenosyl-L-homocysteine
show the reaction diagram
-
18% of the activity with normetanephrine
-
-
?
3-chloro-4-hydroxyphenylethanolamine + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
3-hydroxyphenylethanolamine + S-adenosyl-L-methionine
N-methyl-m-octopamine + S-adenosyl-L-homocysteine
show the reaction diagram
3-trifluoromethylphenylethanolamine + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
?
3-trifluoromethylphenylethanolamine + S-adenosyl-L-methionine
N-methyl-3-trifluoromethylphenylethanolamine + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
?
4-hydroxynorephedrine + S-adenosyl-L-methionine
4-hydroxyephedrine + S-adenosyl-L-homocysteine
show the reaction diagram
-
18% of the activity with normetanephrine
-
-
?
4-hydroxyphenylethanolamine + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
-
i.e. octopamine
-
-
?
9-methylnorharman + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
anti-9-amino-6-(trifluoromethyl)benzonorbornene + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
?
cis-(1R,2S)-2-amino-1-tetralol + S-adenosyl-L-methionine
cis-(1R,2S)-2-methylamino-1-tetralol + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
?
D-norepinephrine + S-adenosyl-L-methionine
epinephrine + S-adenosyl-L-homocysteine
show the reaction diagram
DL-m-hydroxyphenylethanolamine + S-adenosyl-L-methionine
neosynephrine + S-adenosyl-L-homocysteine
show the reaction diagram
-
60% of the activity with normetanephrine
-
-
?
DL-neo-synephrine + S-adenosyl-L-methionine
3-hydroxy-alpha-[(dimethylamine)methyl]benzenemethanol + S-adenosyl-L-homocysteine
show the reaction diagram
-
20% of the activity with normetanephrine
-
-
?
DL-octopamine + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
-
18% of the activity with normetanephrine
-
-
?
dopamine + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
epinephrine + S-adenosyl-L-methionine
? + D-adenosylhomocysteine
show the reaction diagram
-
-
-
-
?
L-norephedrine + S-adenosyl-L-methionine
ephedrine + S-adenosyl-L-homocysteine
show the reaction diagram
-
14% of the activity with normetanephrine
-
-
?
L-norepinephrine + S-adenosyl-L-methionine
epinephrine + S-adenosyl-L-homocysteine
show the reaction diagram
norepinephrine + S-adenosyl-L-methionine
epinephrine + S-adenosyl-L-homocysteine
show the reaction diagram
normetanephrine + S-adenosyl-L-methionine
metanephrine + S-adenosyl-L-homocysteine
show the reaction diagram
octopamine + S-adenosyl-L-methionine
N-methyloctopamine + S-adenosyl-L-homocysteine
show the reaction diagram
phenylethanolamine + S-adenosyl-L-methionine
N-methylphenylethanolamine + S-adenosyl-L-homocysteine
show the reaction diagram
S-adenosyl-L-methionine + 4-aminomethyl-1,2,3,4-tetrahydroisoquinoline
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + noradrenaline
S-adenosyl-L-homocysteine + epinephrine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + norepinephrine
S-adenosyl-L-homocysteine + epinephrine
show the reaction diagram
S-adenosyl-L-methionine + phenylethanolamine
S-adenosyl-L-homocysteine + N-methylphenylethanolamine
show the reaction diagram
additional information
?
-