2.1.1.28: phenylethanolamine N-methyltransferase
This is an abbreviated version!
For detailed information about phenylethanolamine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.28
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2.1.1.28
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catecholamine
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medulla
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hydroxylase
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adrenergic
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dopamine
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chromaffin
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beta-hydroxylase
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glucocorticoid
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sympathetic
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rostrally
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catecholaminergic
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noradrenergic
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innervation
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ventrolateral
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hypothalamic
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corticosterone
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catecholamine-synthesizing
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oblongata
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dopamine-beta-hydroxylase
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pnmt-immunoreactive
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perikarya
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tractus
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adrenomedullary
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proenkephalin
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dorsomedial
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sympathoadrenal
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intermediolateral
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alpha2-adrenoceptor
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1,2,3,4-tetrahydroisoquinoline
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coeruleus
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phenylethanolamine-n-methyltransferase
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postrema
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pnmt-ir
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medicine
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bulbospinal
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normetanephrine
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solitarii
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analysis
- 2.1.1.28
- catecholamine
- medulla
- hydroxylase
-
adrenergic
- dopamine
-
chromaffin
- beta-hydroxylase
- glucocorticoid
-
sympathetic
-
rostrally
-
catecholaminergic
-
noradrenergic
-
innervation
-
ventrolateral
- hypothalamic
- corticosterone
-
catecholamine-synthesizing
- oblongata
- dopamine-beta-hydroxylase
-
pnmt-immunoreactive
- perikarya
-
tractus
-
adrenomedullary
- proenkephalin
-
dorsomedial
-
sympathoadrenal
-
intermediolateral
-
alpha2-adrenoceptor
- 1,2,3,4-tetrahydroisoquinoline
-
coeruleus
-
phenylethanolamine-n-methyltransferase
-
postrema
-
pnmt-ir
- medicine
-
bulbospinal
- normetanephrine
-
solitarii
- analysis
Reaction
Synonyms
hPNMT, methyltransferase, noradrenaline N-, NMT, noradrenalin methyltransferase, noradrenalin N-methyltransferase, noradrenaline N-methyltransferase, norepinephrin N-methyltransferase, norepinephrine methyltransferase, norepinephrine N-methyltransferase, phenethanolamine methyltransferase, phenethanolamine N-methyltransferase, PNMT
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 2.1.1.28 - phenylethanolamine N-methyltransferase
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REACTION DIAGRAM
9-methylnorharman + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
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PNMT catalyzes the 2N-methylation of beta-carbolines, forming 2N-methylated beta-carbolinium cations, which are structural and functional analogs of the Parkinsonian-inducing toxin MPP+
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-
?
S-adenosyl-L-methionine + phenylethanolamine
S-adenosyl-L-homocysteine + N-methylphenylethanolamine
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-
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?
S-adenosyl-L-homocysteine + epinephrine
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last step in biosynthesis of epinephrine
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-
?
S-adenosyl-L-methionine + norepinephrine
S-adenosyl-L-homocysteine + epinephrine
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terminal step in epinephrine biosynthesis
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-
?
S-adenosyl-L-methionine + norepinephrine
S-adenosyl-L-homocysteine + epinephrine
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epinephrine is an important neurotransmitter and hormone, and epinephrine is required for normal blood pressure and cardiac filling responses to stress, but is not required for tachycardia during stress or normal cardiovascular function at rest
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-
?
S-adenosyl-L-methionine + norepinephrine
S-adenosyl-L-homocysteine + epinephrine
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epinephrine is an important neurotransmitter and hormone, and epinephrine is required for normal blood pressure and cardiac filling responses to stress, but is not required for tachycardia during stress or normal cardiovascular function at rest
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-
?
S-adenosyl-L-methionine + norepinephrine
S-adenosyl-L-homocysteine + epinephrine
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last step in biosynthesis of epinephrine
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?
?
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enzyme is involved in biosynthesis of epinephrine
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-
?
additional information
?
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the enzyme is involved in norepinephrine pathways
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?
additional information
?
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the phenylethanolamine N-methyltransferase GRE plays a necessary, but not sufficient role in the transcriptional aspects to the control mechanism. Analyses implicate the participation of sequences in the distal 5´promoter of this gene.
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?
additional information
?
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terminal enzyme in the biosynthetic pathway for epinephrine
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?
additional information
?
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final enzyme in the pathway for epinephrine biosynthesis
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-
?
additional information
?
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the enzyme binds to the alpha-adrenoreceptor
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-
?