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2.1.1.28: phenylethanolamine N-methyltransferase

This is an abbreviated version!
For detailed information about phenylethanolamine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.28

Reaction

S-adenosyl-L-methionine
+
phenylethanolamine
=
S-adenosyl-L-homocysteine
 +
N-Methylphenylethanolamine

Synonyms

hPNMT, methyltransferase, noradrenaline N-, NMT, noradrenalin methyltransferase, noradrenalin N-methyltransferase, noradrenaline N-methyltransferase, norepinephrin N-methyltransferase, norepinephrine methyltransferase, norepinephrine N-methyltransferase, phenethanolamine methyltransferase, phenethanolamine N-methyltransferase, PNMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.28 phenylethanolamine N-methyltransferase

KI Value

KI Value on EC 2.1.1.28 - phenylethanolamine N-methyltransferase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0096
(6R)-6-methyl-2-nitro-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
-
R-isomer, pH 8.0, 37°C
0.15
(6R)-6-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carbonitrile
-
R-isomer, pH 8.0, 37°C
0.00031
(6S)-6-methyl-2-nitro-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
-
S-isomer, pH 8.0, 37°C
0.0033
(6S)-6-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carbonitrile
-
S-isomer, pH 8.0, 37°C
0.000017 - 0.000145
(7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl)methanol
0.0383
(R)-3-methyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.00101
(S)-3-methyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.00049
1,2,3,4-tetrahydrobenz[h]isoquinoline
0.0058
1,2,3,4-tetrahydroisoquinoline
0.47
1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid
-
-
0.00012 - 0.0069
1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
0.00009
1-(2,3-dichlorophenyl)ethanamine
-
pH 8.0
0.061
1-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)ethanone
-
pH 8.0, 37°C
0.45
1-thiophen-2-ylmethanamine
-
pH 8.0, 37°C
0.11
1-thiophen-3-ylmethanamine
-
pH 8.0, 37°C
0.00334
2,3,4,5-tetrahydro-1H-2-benzazepine
-
-
0.028
2,3,4,5-tetrahydro-5H-1,4-benzodiazepine
-
-
0.0041
2,3,4,5-tetrahydro-5H-1,4-benzothiazepine
-
-
0.0212
2,3,4,5-tetrahydro-5H-1,4-benzoxazepine
-
-
0.000072 - 0.00133
2,3-dichloro-alpha-methylbenzylamine
0.0012
2-bromo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
-
pH 8.0, 37°C
0.00073 - 0.021
2-bromo-6-(trifluoromethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
0.025
2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
-
pH 8.0, 37°C
0.0026
2-nitro-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
-
pH 8.0, 37°C
0.22
2-Phenylethylamine
-
pH 8.0, 37°C
0.3
2-thiophen-2-ylethanamine
-
pH 8.0, 37°C
0.00227 - 0.0148
3,4-dichloroamphetamine
0.508 - 0.909
3,4-Dichlorophenylethanolamine
1.138 - 1.522
3,4-dichlorophenylethylenediamine
0.00082
3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.00015
3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
-
pH 8.0, 37°C
0.0000018 - 0.000315
3-(fluoromethyl)-7-(thiomorpholin-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinoline
0.00015
3-(fluoromethyl)-7-nitro-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.00013
3-(fluoromethyl)-N-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
-
pH 8.0, 37°C
0.000017 - 0.000035
3-(fluoromethyl)-N-(3,3,3-trifluoropropyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
0.017
3-(trifluoromethyl)-1,2,3,4-tetrahydro[1]benzothieno[3,2-c]pyridine
-
pH 8.0, 37°C
0.0066
3-butyl-7-nitro-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.0034
3-difluoromethyl-1,2,3,4-tetrahydroisoquinoline
-
radiochemical assay, inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate, and three concentrations of inhibitor
0.0032
3-difluoromethyl-7-(ethylaminosulfonyl)-1,2,3,4-tetrahydroisoquinoline
-
radiochemical assay, inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate, and three concentrations of inhibitor
0.00025
3-difluoromethyl-7-(N-2,2,2-trifluoroethylaminosulfonyl)-1,2,3,4-tetrahydroisoquinoline
-
radiochemical assay, inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate, and three concentrations of inhibitor
0.0053
3-difluoromethyl-7-(N-3-methoxypropylaminosulfonyl)-1,2,3,4-tetrahydroisoquinoline
-
radiochemical assay, inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate, and three concentrations of inhibitor
0.037
3-difluoromethyl-7-(N-4-nitrophenylaminosulfonyl)-1,2,3,4-tetrahydroisoquinoline
-
radiochemical assay, inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate, and three concentrations of inhibitor
0.0021
3-difluoromethyl-7-(propylaminosulfonyl)-1,2,3,4-tetrahydroisoquinoline
-
radiochemical assay, inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate, and three concentrations of inhibitor
0.000094
3-difluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline
-
radiochemical assay, inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate, and three concentrations of inhibitor
0.0031
3-difluoromethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline
-
radiochemical assay, inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate, and three concentrations of inhibitor
0.0002
3-difluoromethyl-7-iodo-1,2,3,4-tetrahydroisoquinoline
-
radiochemical assay, inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate, and three concentrations of inhibitor
0.006
3-difluoromethyl-7-methylsulfonyl-1,2,3,4-tetrahydroisoquinoline
-
radiochemical assay, inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate, and three concentrations of inhibitor
0.00017
3-difluoromethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline
-
radiochemical assay, inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate, and three concentrations of inhibitor
0.000067
3-difluoromethyl-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
-
radiochemical assay, inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate, and three concentrations of inhibitor
0.0018
3-ethyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
-
pH 8.0, 37°C
0.00049
3-ethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.00051
3-ethyl-N-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
-
pH 8.0, 37°C
0.0014
3-fluoromethyl-7-(2,2,2-trifluoroethylsulfonyl)-1,2,3,4-tetrahydroisoquinoline
inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate and three concentrations of inhibitor with a radiochemical assay.
0.0013
3-fluoromethyl-7-(3,3,3-trifluoropropylsulfonyl)-1,2,3,4-tetrahydroisoquinoline
inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate and three concentrations of inhibitor with a radiochemical assay.
0.067
3-fluoromethyl-7-(4,4,4-trifluorobutylsulfonyl)-1,2,3,4-tetrahydroisoquinoline
inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate and three concentrations of inhibitor with a radiochemical assay.
0.032
3-fluoromethyl-7-(4-chlorobenzylsulfonyl)-1,2,3,4-tetrahydroisoquinoline
inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate and three concentrations of inhibitor with a radiochemical assay.
0.0065
3-fluoromethyl-7-(N-benzylaminosulfonyl)-1,2,3,4-tetrahydrosioquinoline
-
-
0.0024
3-fluoromethyl-7-(N-methylaminosulfonyl)-1,2,3,4-tetrahydroisoquinoline
-
-
0.00066
3-fluoromethyl-7-aminosulfonyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.0017
3-fluoromethyl-7-azido-1,2,3,4-tetrahydrosioquinoline
-
-
0.00064
3-fluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline
-
-
0.0011
3-fluoromethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline
-
-
0.000073 - 0.00021
3-fluoromethyl-7-iodo-1,2,3,4-tetrahydroisoquinoline
0.00057
3-fluoromethyl-7-isothiocyanato-1,2,3,4-tetrahydroisoquinoline
-
-
0.0016
3-fluoromethyl-7-methanesulfonyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.54
3-fluoromethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline
-
-
0.0024
3-fluoromethyl-7-propylsulfonyl-1,2,3,4-tetrahydroisoquinoline
inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate and three concentrations of inhibitor with a radiochemical assay.
0.00032
3-fluoromethyl-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.00074
3-fluoromethyl-7-[N-(4-chlorophenyl)aminosulfonyl]-1,2,3,4-tetrahydroisoquinoline
-
-
0.00035
3-hydroxyethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline
-
-
0.00051
3-hydroxyethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline
0.000047
3-hydroxymethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0
0.0017
3-hydroxypropyl-7-bromo-1,2,3,4-tetrahydroisoquinoline
-
-
0.0014
3-hydroxypropyl-7-nitro-1,2,3,4-tetrahydroisoquinoline
0.0046
3-isopropyl-7-nitro-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.0014
3-methyl-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.000077
3-methyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
-
pH 8.0, 37°C
0.000067
3-methyl-1,2,3,4-tetrahydro[1]benzothieno[3,2-c]pyridine
-
pH 8.0, 37°C
0.000072
3-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.000034
3-methyl-N-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
-
pH 8.0, 37°C
0.00012
3-propyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
-
pH 8.0, 37°C
0.00092
3-propyl-N-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
-
pH 8.0, 37°C
0.015
3-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.00052
3-trifluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline
-
-
0.013
3-trifluoromethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline
-
-
0.002
3-trifluoromethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline
-
-
0.037
4,5,6,7-tetrahydrothieno[3,2-c]pyridine
-
pH 8.0, 37°C
0.015
4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carbonitrile
-
pH 8.0, 37°C
0.1
4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxamide
-
pH 8.0, 37°C
0.00027
5,6-Dichloro-2-aminotetralin
-
-
0.04
6-(trifluoromethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
-
pH 8.0, 37°C
0.0058
6-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
-
pH 8.0, 37°C
0.0000016 - 0.0000031
7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
0.072
7-(3-methoxypropylsulfonyl)-3-fluoromethyl-1,2,3,4-tetrahydroisoquinoline
inhibition constants are determined using four concentrations of phenylethanolamnie as the variable substrate and three concentrations of inhibitor with a radiochemical assay.
0.0009
7-(N-4-chlorophenylaminosulfonyl)-3-difluoromethyl-1,2,3,4-tetrahydroisoquinoline
-
radiochemical assay, inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate, and three concentrations of inhibitor
0.0056
7-(N-butylaminosulfonyl)-3-difluoromethyl-1,2,3,4-tetrahydroisoquinoline
-
radiochemical assay, inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate, and three concentrations of inhibitor
0.19
7-acetamido-1,2,3,4-tetrahydroisoquinoline
-
-
0.0098
7-allylsulfonyl-1,2,3,4-tetrahydrosioquinoline
-
-
0.064
7-aminocarbonyl-1,2,3,4-tetrahydroisoquinoline
-
-
1.9
7-aminomethyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride
-
-
0.033
7-aminosulfonyl-1,2,3,4-tetrahydrobenz[h]isoquinoline
-
-
0.00068
7-aminosulfonyl-3-difluoromethyl-1,2,3,4-tetrahydroisoquinoline
-
radiochemical assay, inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate, and three concentrations of inhibitor
0.0029
7-benzoyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.061
7-benzyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.00022
7-bromo-1,2,3,4-tetrahydrobenzo[h]isoquinoline
-
-
0.00022
7-bromo-1,2,3,4-tetrahydrobenz[h]isoquinoline
0.000056
7-bromo-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.000023
7-bromo-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.0076
7-bromo-3-butyl-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.00048
7-bromo-3-ethyl-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.00035
7-bromo-3-hydroxyethyl-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0
0.000012
7-bromo-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0
0.0017
7-bromo-3-hydroxypropyl-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0
0.0044
7-bromo-3-isopropyl-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.000017
7-bromo-3-methyl-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.011
7-bromo-3-pentyl-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.00048
7-bromo-3-propyl-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.00029
7-bromo-N-triphenylmethyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.018
7-butylsulfonyl-3-fluoromethyl-1,2,3,4-tetrahydroisoquinoline
inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate and three concentrations of inhibitor with a radiochemical assay.
0.0023
7-cyano-1,2,3,4-tetrahydrobenz[h]isoquinoline
-
-
0.014
7-ethylsulfonyl-3-fluoromethyl-1,2,3,4-tetrahydroisoquinoline
inhibition constants are determine using four concentrations of phenylethanolamnie as the variable substrate and three concentrations of inhibitor with a radiochemical assay.
0.00091
7-hydroxy-1,2,3,4-tetrahydrobenz[h]isoquinoline
-
-
0.011
7-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline oxalate
-
-
0.00004 - 0.00074
7-iodo-1,2,3,4-tetrahydroisoquinoline
0.0021
7-methoxy-1,2,3,4-tetrahydrobenz[h]isoquinoline
-
-
0.0067
7-methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.045
7-methylsulfinyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.0013
7-methylsulfonyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.036
7-methylsulfonyl-3-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.00061
7-methylthio-1,2,3,4-tetrahydroisoquinoline
-
-
0.0009
7-nitro-1,2,3,4-tetrahydrobenz[h]isoquinoline
-
-
0.00004 - 0.067
7-nitro-1,2,3,4-tetrahydroisoquinoline
0.0098
7-nitro-3-pentyl-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.00053
7-nitro-3-propyl-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0, 37°C
0.014
7-phenylsulfonyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.00028 - 0.00056
7-sulfonamido-1,2,3,4-tetrahydroisoquinoline
0.0013
7-trichloromethylsulfonyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.0057
7-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.00018
7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
-
-
0.0000044 - 0.00026
8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine
0.17
benzylamine
-
pH 8.0, 37°C
0.109 - 8.298
D-norepinephrine
8
dopamine
-
competitive with phenylethanolamine
0.054
epinephrine
-
-
0.165 - 0.631
L-norepinephrine
0.0000044 - 0.00312
LY134046
0.0000013 - 0.00021
N-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
0.000001 - 0.00027
N-(4-chlorophenyl)-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
0.0000014 - 0.000039
N-(4-chlorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
0.0059
norepinephrine
-
noncompetitive with phenylethanolamine
3.6
Phenylethylamine
-
competitive with phenylethanolamine
0.0000049
R-(+)-7-bromo-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline
-
pH 8.0
0.0124 - 0.0894
S-adenosyl-L-methionine
0.000057 - 0.321
SKF 29661
0.00000155 - 0.001375
SKF 64139
0.0021
trans-(1S,2S)-2-amino-1-tetralol
wild type enzyme, assay mixture consists of 25 microl of 0.5 M phosphate buffer (pH 8.0), 5 microl of [methyl-3H]S-adenosyl-L-methionine containing approximately 2.5 X 10 00000 dpm, varying amounts of phenylethanolamine and unlabeled S-adenosyl-L-methionine, 20 microl enzyme and water at 30°C. The concentration of S-adenosyl-L-methionine is fixed on 5 microM.
additional information
additional information
-