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2.1.1.261: 4-dimethylallyltryptophan N-methyltransferase

This is an abbreviated version!
For detailed information about 4-dimethylallyltryptophan N-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
4-dimethylallyl-L-tryptophan
=
S-adenosyl-L-homocysteine
+
4-dimethylallyl-L-abrine

Synonyms

easF, fgaMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.261 4-dimethylallyltryptophan N-methyltransferase

Cloned

Cloned on EC 2.1.1.261 - 4-dimethylallyltryptophan N-methyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene easF, a fragment of genomic DNA containing dmaW, easF, easE, and easC is amplified from the human-pathogenic, ergot alkaloid-producing fungus Aspergillus fumigatus and transformed into Aspergillus nidulans strain FGSC A767, a model fungus that does not contain any of the ergot alkaloid synthesis genes. Transformed Aspergillus nidulans strains produces chanoclavine-I and an earlier pathway intermediate
gene fgaMT, DNA and amino acid sequence determination and analysis, overexpression of the soluble His6-tagged enzyme in Escherichia coli strain XL-1 blue MRF-
recombinant heterologous enzyme expression in Aspergillus nidulans
-