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2.1.1.257: tRNA (pseudouridine54-N1)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (pseudouridine54-N1)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.257

Reaction

S-adenosyl-L-methionine
+
pseudouridine54 in tRNA
=
S-adenosyl-L-homocysteine
+
N1-methylpseudouridine54 in tRNA

Synonyms

COG 1901, COG1901, DUF358, DUF358/Mj1640, Emg1, Hvo_1989, m1-pseudouridine methyltransferase, m1G, m1PSI methyltransferase, M3U, Mja_1640, MjNep1, Nep1, Pfam DUF358, pseudouridine N1-specific methyltransferase, pseudouridine-N1-specific methyltransferase, ribosome assembly factor Nep1, SAM-dependent N1-pseudouridine methyltransferase, TrmY, TrmY protein

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.257 tRNA (pseudouridine54-N1)-methyltransferase

Systematic Name

Systematic Name on EC 2.1.1.257 - tRNA (pseudouridine54-N1)-methyltransferase

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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:tRNA (pseudouridine54-N1)-methyltransferase
While this archaeal enzyme is specific for the 54 position and does not methylate pseudouridine at position 55, the presence of pseudouridine at position 55 is necessary for the efficient methylation of pseudouridine at position 54 [2,3].