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2.1.1.25: phenol O-methyltransferase

This is an abbreviated version!
For detailed information about phenol O-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
phenol
=
S-adenosyl-L-homocysteine
 +
anisole

Synonyms

methyltransferase, phenol, PMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.25 phenol O-methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.25 - phenol O-methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 2,4-dibromophenol
S-adenosyl-L-homocysteine + 2,4-dibromo-1-methoxybenzene
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + 2,4-dichlorophenol
S-adenosyl-L-homocysteine + 2,4-dichloro-1-methoxybenzene
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + 4-hydroxy-3,5-dimethoxyacetophenone
S-adenosyl-L-homocysteine + 3,4,5-trimethoxyacetophenone
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + 4-hydroxy-3,5-dimethoxybenzaldehyde
S-adenosyl-L-homocysteine + 3,4,5-trimethoxybenzaldehyde
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + 4-hydroxy-3,5-dimethoxybenzoic acid
S-adenosyl-L-homocysteine + 3,4,5-trimethoxybenzoic acid
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + 4-hydroxy-3-methoxyacetophenone
S-adenosyl-L-homocysteine + 3,4-dimethoxyacetophenone
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + 4-hydroxy-3-methoxybenzaldehyde
S-adenosyl-L-homocysteine + 3,4-dimethoxybenzaldehyde
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + 4-hydroxy-3-methoxybenzoic acid
S-adenosyl-L-homocysteine + 3,4-dimethoxybenzoic acid
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + acetaminophen
S-adenosyl-L-homocysteine + N-(4-methoxyphenyl)-acetamide
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + m-bromophenol
S-adenosyl-L-homocysteine + m-bromoanisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + m-chlorophenol
S-adenosyl-L-homocysteine + m-chloroanisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + m-methoxyphenol
S-adenosyl-L-homocysteine + 1,3-dimethoxybenzene
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + m-nitrophenol
S-adenosyl-L-homocysteine + m-nitroanisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + o-chlorophenol
S-adenosyl-L-homocysteine + o-chloroanisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + o-methoxyphenol
S-adenosyl-L-homocysteine + veratrole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + o-methylphenol
S-adenosyl-L-homocysteine + o-methylanisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + p-chlorophenol
S-adenosyl-L-homocysteine + p-chloroanisole
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + p-ethylphenol
S-adenosyl-L-homocysteine + p-ethylanisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + p-hydroxyacetanilide
S-adenosyl-L-homocysteine + p-methoxyacetanilide
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + p-methoxyphenol
S-adenosyl-L-homocysteine + 1,4-dimethoxybenzene
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + p-methylphenol
S-adenosyl-L-homocysteine + p-methylanisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + phenol
S-adenosyl-L-homocysteine + anisole
show the reaction diagram
additional information
?
-
-
3-methoxy- and 3,5-dimethoxy-substituted 4-hydroxy-benzaldehydes, -benzoic acids, and -acetophenones are the preferred substrates. The corresponding 3,4-dihydroxy compounds are methylated relatively slowly, while the 3-hydroxy-4-methoxy compounds are almost inactive as substrates. Substituents in both the 2 and 4 positions relative to the hydroxyl group appear to be essential for significant enzyme attack of a substrate. Xenobiotic compounds such as 2,4-dichlorophenol and 2,4-dibromophenol are methylated almost as readily as 4-hydroxy-3-methoxyacetophenone. No substrates: homovanillic acid, caffeic acid, ferulic acid
-
-
?