2.1.1.248: methylamine-corrinoid protein Co-methyltransferase

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For detailed information about methylamine-corrinoid protein Co-methyltransferase, go to the full flat file.

Reaction

Synonyms

corrinoid-dependent methylamine methyltransferase, MMA methyltransferase, MMA:CoM methyltransferase, MMA:MMCP methyltransferase, MMAMT, monomethylamine methyltransferase, monomethylamine:coenzyme M methyl transferase, monomethylamine:MMCP methyltransferase, MtmB, mtmB1, mtmB2

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.248 methylamine-corrinoid protein Co-methyltransferase

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Results	in table
1	Activating Compound
410	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
2	Crystallization (Commentary)
2	Expression
9	General Information
4	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
15	Organism
3	Pathway
1	pH Optimum
3	Purification (Commentary)
1	Reaction
11	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
10	Substrates and Products (Substrate)
7	Subunits
23	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.1.1.248 - methylamine-corrinoid protein Co-methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

monomethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase

The enzyme, which catalyses the transfer of a methyl group from methylamine to a methylamine-specific corrinoid protein (MtmC), is involved in methanogenesis from methylamine. The enzyme contains the unusual amino acid pyrrolysine [3]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase.