2.1.1.244: protein N-terminal methyltransferase
This is an abbreviated version!
For detailed information about protein N-terminal methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.244
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2.1.1.244
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methyltransferases
-
rna-dependent
-
mtase
-
trimethylation
-
dengue
-
flavivirus
-
bisubstrate
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methyltransferase-like
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drug development
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pharmacology
- 2.1.1.244
- methyltransferases
-
rna-dependent
- mtase
-
trimethylation
- dengue
- flavivirus
-
bisubstrate
-
methyltransferase-like
- drug development
- pharmacology
Reaction
2 S-adenosyl-L-methionine
+
Synonyms
alpha-N-methyltransferase, alpha-N-terminal methyltransferase 1, alphaN-methyltransferase, CG1675, dNTMT, EEF1A lysine methyltransferase 1, eEF1A-KMT1, EEF1AKMT1, Efm5, Efm7, elongation factor methyltransferase 7, FEAT, METT11B, METTL11A, METTL11a/C9orf32/Ad-003, METTL13, METTL13/FEAT, N-terminal and lysine methyltransferase, N-terminal methyltransferase, N-terminal methyltransferase 1, N-terminal RCC1 methyltransferase, N-terminal RCC1 methyltransferase 1, N-terminal Xaa-Pro-Lys N-methyltransferase 1, N6AMT2, NMT1, NNT1, NRMT, NRMT1, Ntm1, NTMT1, peptide N-terminal methyltransferase, PrmA, protein methyltransferase, protein N-terminal methyltransferase 1, Rkm2, SS alphaN-methyltransferase, SSMT, TAE1, YBR261C, YBR261C/Tae1, YGR001C, YLR285W
ECTree
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Reference on EC 2.1.1.244 - protein N-terminal methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ying, Z.; Mulligan, R.; Janney, N.; Royer, M.; Houtz, R.
Related alphaN- and epsilonN-methyltransferases methylate the large and small subunits of Rubisco
Acta Biol. Hung.
49
173-184
1998
Spinacia oleracea
Webb, K.J.; Lipson, R.S.; Al-Hadid, Q.; Whitelegge, J.P.; Clarke, S.G.
Identification of protein N-terminal methyltransferases in yeast and humans
Biochemistry
49
5225-5235
2010
Saccharomyces cerevisiae, Mus musculus, Homo sapiens (Q9BV86), Homo sapiens
Richon, V.M.; Johnston, D.; Sneeringer, C.J.; Jin, L.; Majer, C.R.; Elliston, K.; Jerva, L.F.; Scott, M.P.; Copeland, R.A.
Chemogenetic analysis of human protein methyltransferases
Chem. Biol. Drug Des.
78
199-210
2011
Homo sapiens
Webb, K.; Laganowsky, A.; Whitelegge, J.; Clarke, S.
Identification of two SET domain proteins required for methylation of lysine residues in yeast ribosomal protein Rpl42ab
J. Biol. Chem.
283
35561-35568
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
Tooley, C.E.; Petkowski, J.J.; Muratore-Schroeder, T.L.; Balsbaugh, J.L.; Shabanowitz, J.; Sabat, M.; Minor, W.; Hunt, D.F.; Macara, I.G.
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein
Nature
466
1125-1128
2010
Homo sapiens
Dong, C.; Mao, Y.; Tempel, W.; Qin, S.; Li, L.; Loppnau, P.; Huang, R.; Min, J.
Structural basis for substrate recognition by the human N-terminal methyltransferase 1
Genes Dev.
29
2343-2348
2015
Homo sapiens
Richardson, S.L.; Mao, Y.; Zhang, G.; Hanjra, P.; Peterson, D.L.; Huang, R.
Kinetic mechanism of protein N-terminal methyltransferase 1
J. Biol. Chem.
290
11601-11610
2015
Homo sapiens
Bonsignore, L.A.; Butler, J.S.; Klinge, C.M.; Schaner Tooley, C.E.
Loss of the N-terminal methyltransferase NRMT1 increases sensitivity to DNA damage and promotes mammary oncogenesis
Oncotarget
6
12248-12263
2015
Homo sapiens
Zhang, G.; Richardson, S.L.; Mao, Y.; Huang, R.
Design, synthesis, and kinetic analysis of potent protein N-terminal methyltransferase 1 inhibitors
Org. Biomol. Chem.
13
4149-4154
2015
Homo sapiens
Jia, K.; Huang, G.; Wu, W.; Shrestha, R.; Wu, B.; Xiong, Y.; Li, P.
In vivo methylation of OLA1 revealed by activity-based target profiling of NTMT1
Chem. Sci.
10
8094-8099
2019
Homo sapiens (Q9BV86)
Huang, R.
Chemical biology of protein N-terminal methyltransferases
ChemBioChem
20
976-984
2019
Escherichia coli (P0A8T1), Saccharomyces cerevisiae (P38340), Saccharomyces cerevisiae (Q05874), Drosophila melanogaster (Q6NN40), Thermus thermophilus (Q84BQ9), Homo sapiens (Q8N6R0), Homo sapiens (Q9BV86), Thermus thermophilus DSM 579 (Q84BQ9), Saccharomyces cerevisiae ATCC 204508 (P38340), Saccharomyces cerevisiae ATCC 204508 (Q05874), Thermus thermophilus ATCC 27634 (Q84BQ9)
Dong, C.; Dong, G.; Li, L.; Zhu, L.; Tempel, W.; Liu, Y.; Huang, R.; Min, J.
An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2
Commun. Biol.
1
183
2018
Homo sapiens (Q9BV86), Homo sapiens
Wu, R.; Yue, Y.; Zheng, X.; Li, H.
Molecular basis for histone N-terminal methylation by NRMT1
Genes Dev.
29
2337-2342
2015
Homo sapiens (Q9BV86), Homo sapiens
Chen, D.; Dong, G.; Noinaj, N.; Huang, R.
Discovery of bisubstrate inhibitors for protein N-terminal methyltransferase 1
J. Med. Chem.
62
3773-3779
2019
Homo sapiens (Q9BV86)
Hamey, J.J.; Winter, D.L.; Yagoub, D.; Overall, C.M.; Hart-Smith, G.; Wilkins, M.R.
Novel N-terminal and lysine methyltransferases that target translation elongation factor 1A in yeast and human
Mol. Cell. Proteomics
15
164-176
2016
Saccharomyces cerevisiae (P53200), Saccharomyces cerevisiae (Q05874), Saccharomyces cerevisiae, Homo sapiens (Q8WVE0), Homo sapiens, Saccharomyces cerevisiae ATCC 204508 (P53200), Saccharomyces cerevisiae ATCC 204508 (Q05874)
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