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2.1.1.244: protein N-terminal methyltransferase

This is an abbreviated version!
For detailed information about protein N-terminal methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.244

Reaction

2 S-adenosyl-L-methionine +

N-terminal-PPK-[protein]
= 2 S-adenosyl-L-homocysteine +
N-terminal-N,N-dimethyl-N-PPK-[protein]

Synonyms

alpha-N-methyltransferase, alpha-N-terminal methyltransferase 1, alphaN-methyltransferase, CG1675, dNTMT, EEF1A lysine methyltransferase 1, eEF1A-KMT1, EEF1AKMT1, Efm5, Efm7, elongation factor methyltransferase 7, FEAT, METT11B, METTL11A, METTL11a/C9orf32/Ad-003, METTL13, METTL13/FEAT, N-terminal and lysine methyltransferase, N-terminal methyltransferase, N-terminal methyltransferase 1, N-terminal RCC1 methyltransferase, N-terminal RCC1 methyltransferase 1, N-terminal Xaa-Pro-Lys N-methyltransferase 1, N6AMT2, NMT1, NNT1, NRMT, NRMT1, Ntm1, NTMT1, peptide N-terminal methyltransferase, PrmA, protein methyltransferase, protein N-terminal methyltransferase 1, Rkm2, SS alphaN-methyltransferase, SSMT, TAE1, YBR261C, YBR261C/Tae1, YGR001C, YLR285W

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.244 protein N-terminal methyltransferase

Inhibitors

Inhibitors on EC 2.1.1.244 - protein N-terminal methyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5'-([3-[(2S)-2-acetylpyrrolidin-1-yl]propyl][(3S)-3-amino-3-carboxypropyl]amino)-5'-deoxyadenosine
-
me3-RCC1-6
-
product inhibition
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N-terminal-acetyl-SPKRIAKRRS-[RCC1]
-
noncompetitive versus S-adenosyl-L-methionine and protein substrate
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N-terminal-trimethyl-SPKRIA-[RCC1]
-
product inhibition, competitive inhibitor versus protein substrate, noncompetitive versus S-adenosyl-L-methionine
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NAM-C3-GPRRRS
NAM-C3-PKRIA-NH2
discovery of the potent NTMT1 bisubstrate inhibitor NAM-C3-PKRIA-NH2 that exhibits greater than 100fold selectivity against a panel of methyltransferases. Crystal structure analysis of NTMT1 in complex with the inhibitor reveals that NAM-C3-PKRIA-NH2 occupies substrate and cofactor binding sites of NTMT1
NAM-C3-PPKR-NH2
-
NAM-C3-PRRRS-NH2
-
NAM-TZ-SPKRIA
S-adenosyl-L-homocysteine
sinefungin
-
noncompetitive versus S-adenosyl-L-methionine and protein substrate
additional information
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