2.1.1.244: protein N-terminal methyltransferase

This is an abbreviated version!
For detailed information about protein N-terminal methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.244

2.1.1.244

methyltransferases

rna-dependent

mtase

trimethylation

dengue

flavivirus

bisubstrate

methyltransferase-like

drug development

pharmacology

Reaction

2 S-adenosyl-L-methionine +

= 2 S-adenosyl-L-homocysteine +

Synonyms

alpha-N-methyltransferase, alpha-N-terminal methyltransferase 1, alphaN-methyltransferase, CG1675, dNTMT, EEF1A lysine methyltransferase 1, eEF1A-KMT1, EEF1AKMT1, Efm5, Efm7, elongation factor methyltransferase 7, FEAT, METT11B, METTL11A, METTL11a/C9orf32/Ad-003, METTL13, METTL13/FEAT, N-terminal and lysine methyltransferase, N-terminal methyltransferase, N-terminal methyltransferase 1, N-terminal RCC1 methyltransferase, N-terminal RCC1 methyltransferase 1, N-terminal Xaa-Pro-Lys N-methyltransferase 1, N6AMT2, NMT1, NNT1, NRMT, NRMT1, Ntm1, NTMT1, peptide N-terminal methyltransferase, PrmA, protein methyltransferase, protein N-terminal methyltransferase 1, Rkm2, SS alphaN-methyltransferase, SSMT, TAE1, YBR261C, YBR261C/Tae1, YGR001C, YLR285W

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.244 protein N-terminal methyltransferase

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Results	in table
3	Activating Compound
39	AA Sequence
3	Application
1	CAS Registry Number
12	Cloned(Commentary)
21	Cofactor
8	Crystallization (Commentary)
111	Disease/ Diagnostics
1	Expression
73	General Information
1	General Stability
6	IC50 Value
18	Inhibitors
19	kcat/KM [mM/s]
3	Ki Value [mM]
27	KM Value [mM]
18	Localization
2	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
60	Organism
30	PDB ID
9	pH Optimum
24	Protein Variants
6	Purification (Commentary)
7	Reaction
28	Reference
18	Source Tissue
133	Substrates and Products (Substrate)
5	Subunits
85	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
19	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.1.1.244 - protein N-terminal methyltransferase

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0.025

me3-RCC1-6

Homo sapiens

above, wild-type enzyme, pH 7.5, 37°C

736186

0.00094

NAM-C3-GPRRRS

Homo sapiens

Q8N6R0, Q9BV86

pH and temperature not specified in the publication

756463

0.000035

NAM-C3-PKRIA-NH2

Homo sapiens

Q9BV86

recombinant His-tagged enzyme, pH 7.5, 37°C

757405

0.00081 - 0.0013

NAM-TZ-SPKRIA

2 entries

0.0033

S-adenosyl-L-homocysteine

Homo sapiens

wild-type enzyme, pH 7.5, 37°C

736186