2.1.1.237: mycinamicin III 3''-O-methyltransferase
This is an abbreviated version!
For detailed information about mycinamicin III 3''-O-methyltransferase, go to the full flat file.
Reaction
Synonyms
MycF
ECTree
2.1.1.237 mycinamicin III 3''-O-methyltransferaseAdvanced search results
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General Information on EC 2.1.1.237 - mycinamicin III 3''-O-methyltransferase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
evolution
structural basis of substrate specificity and regiochemistry in the MycF/TylF family of sugar O-methyltransferases, overview
malfunction
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construction of a MycF disrupion mutant. The disruption mutant mainly produces mycinamicin III
metabolism
the 3'-O-methyltransferase enzyme is involved in the biosynthesis of the macrolide antibiotic mycinamicin
physiological function
additional information
using the MycF substrate complex and the modeled substrate complex of a 4'-specific homologue, active site residues were identified that correlate with the 3' or 4' specificity of MycF family members and define the protein and substrate features that direct the regiochemistry of methyltransfer
physiological function
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the enzyme is involved in the biosynthesis of mycinamicin macrolide antibiotics. Mycinamicins represent a family of macrolide antibiotics with more than twenty members produced by the rare actinomycete Micromonospora griseorubida
physiological function
S-adenosyl-L-methionine cofacor binding induces substantial ordering that creates the binding site for the natural substrate, and a bound metal ion positions the substrate for catalysis
