2.1.1.235: dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase

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For detailed information about dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose

= 2 S-adenosyl-L-homocysteine +

dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-glucopyranose

Synonyms

deoxyamino sugar methyltransferase, N-methyltransferase, TylM1

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.235 dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase

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Results	in table
90	AA Sequence
1	Application
3	Cloned(Commentary)
3	Cofactor
3	Crystallization (Commentary)
6	General Information
4	General Stability
8	kcat/KM [mM/s]
10	KM Value [mM]
1	Metals/Ions
4	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
5	Organism
4	Pathway
12	PDB ID
2	pH Optimum
4	Protein Variants
2	Purification (Commentary)
1	Reaction
5	Reference
1	Storage Stability
11	Substrates and Products (Substrate)
3	Subunits
6	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
9	Turnover Number [1/s]

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Reference on EC 2.1.1.235 - dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase

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714149

Chen, H.; Yamase, H.; Murakami, K.; Chang, C.W.; Zhao, L.; Zhao, Z.; Liu, H.W.

Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine

Biochemistry

9165-9183

2002

Streptomyces fradiae (P95748)

12119032

714271

Carney, A.E.; Holden, H.M.

Molecular architecture of TylM1 from Streptomyces fradiae: an N,N-dimethyltransferase involved in the production of dTDP-D-mycaminose

Biochemistry

780-787

2011

Streptomyces fradiae (P95748), Streptomyces fradiae

21142177

715103

Gandecha, A.R.; Large, S.L.; Cundliffe, E.

Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome

Gene

184

197-203

1997

Streptomyces fradiae (P95748)

9031628

735676

Thoden, J.B.; Holden, H.M.

Production of a novel N-monomethylated dideoxysugar

Biochemistry

1105-1107

2014

Streptomyces fradiae (P95748), Streptomyces fradiae

24512254

756061

Fick, R.J.; Horowitz, S.; McDole, B.G.; Clay, M.C.; Mehl, R.A.; Al-Hashimi, H.M.; Scheiner, S.; Trievel, R.C.

Structural and functional characterization of sulfonium carbon-oxygen hydrogen bonding in the deoxyamino sugar methyltransferase TylM1

Biochemistry

2152-2159

2019

Streptomyces fradiae (P95748), Streptomyces fradiae

30810306