2.1.1.233: [phosphatase 2A protein]-leucine-carboxy methyltransferase

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For detailed information about [phosphatase 2A protein]-leucine-carboxy methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.233

2.1.1.233

demethylation

holoenzyme

methylesterase-1

methylesterification

tauopathies

Reaction

[phosphatase 2A protein]-leucine methyl ester

Synonyms

C-terminal leucine protein carboxyl methyltransferase-1, LCMT-1, LCMT1, leucine carboxy methyltransferase-1, leucine carboxyl methyl transferase 1, leucine carboxyl methyltransferase, leucine carboxyl methyltransferase 1, leucine carboxyl methyltransferase 1 homolog, leucine carboxyl methyltransferase-1, leucine carboxylmethyltransferase-1, leucine carboxymethyltransferase 1/phosphatase methylesterase 1, phosphatase 2A protein methyltransferase, PME-1, PP2A LCMT, PP2A methyltransferase, PP2A-methyltransferase, PP2A-specific methyltransferase, PPM1, Ppm1p, PPMT, protein phosphatase 2A leucine carboxyl methyltransferase, protein phosphatase methyltransferase 1

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.233 [phosphatase 2A protein]-leucine-carboxy methyltransferase

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Results	in table
1	Activating Compound
3696	AA Sequence
7	Cloned(Commentary)
11	Cofactor
3	Crystallization (Commentary)
110	Disease/ Diagnostics
2	Expression
41	General Information
1	IC50 Value
2	Inhibitors
1	KM Value [mM]
11	Localization
5	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
28	Organism
1	pH Optimum
1	pI Value
13	Protein Variants
7	Purification (Commentary)
1	Reaction
28	Reference
48	Source Tissue
2	Specific Activity [micromol/min/mg]
37	Substrates and Products (Substrate)
5	Subunits
65	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.1.233 - [phosphatase 2A protein]-leucine-carboxy methyltransferase

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S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine

S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester

5 entries

S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine309

S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine309 methyl ester

4 entries

S-adenosyl-L-methionine + [phosphatase 2A-C protein]-leucine

S-adenosyl-L-homocysteine + [phosphatase 2A-C protein]-leucine methyl ester

2 entries

S-adenosyl-L-methionine + [protein phosphatase 4 catalytic subunit]-leucine

S-adenosyl-L-homocysteine + [protein phosphatase 4 catalytic subunit]-leucine methyl ester

Mus musculus

A2RTH5

LCMT-1 is the major methyltransferase in embryonic fibroblasts for all three PP2A subfamily phosphatases, PP2Ac, PP4c, and PP6c

751067

S-adenosyl-L-methionine + [protein phosphatase 6 catalytic subunit]-leucine

S-adenosyl-L-homocysteine + [protein phosphatase 6 catalytic subunit]-leucine methyl ester

Mus musculus

A2RTH5

LCMT-1 is the major methyltransferase in embryonic fibroblasts for all three PP2A subfamily phosphatases, PP2Ac, PP4c, and PP6c

751067

additional information

Mus musculus

enzyme LCMT1 is a class 1 S-adenosylmethionine-dependent methyltransferase with PP2A as its only known substrate

737114