2.1.1.233: [phosphatase 2A protein]-leucine-carboxy methyltransferase This is an abbreviated version! For detailed information about [phosphatase 2A protein]-leucine-carboxy methyltransferase, go to the full flat file .
Word Map on EC 2.1.1.233
Reaction
S-adenosyl-L-methionine +
[phosphatase 2A protein]-leucine =
S-adenosyl-L-homocysteine +
[phosphatase 2A protein]-leucine methyl ester
Synonyms C-terminal leucine protein carboxyl methyltransferase-1, LCMT-1, LCMT1, leucine carboxy methyltransferase-1, leucine carboxyl methyl transferase 1, leucine carboxyl methyltransferase, leucine carboxyl methyltransferase 1, leucine carboxyl methyltransferase 1 homolog, leucine carboxyl methyltransferase-1, leucine carboxylmethyltransferase-1, leucine carboxymethyltransferase 1/phosphatase methylesterase 1, phosphatase 2A protein methyltransferase, PME-1, PP2A LCMT, PP2A methyltransferase, PP2A-methyltransferase, PP2A-specific methyltransferase, PPM1, Ppm1p, PPMT, protein phosphatase 2A leucine carboxyl methyltransferase, protein phosphatase methyltransferase 1
ECTree
Engineering
Engineering on EC 2.1.1.233 - [phosphatase 2A protein]-leucine-carboxy methyltransferase
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C36A
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the mutant shows about wild type activity
D303R
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the mutant shows less than 10% activity compared to the wild type enzyme
E65R
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the mutant shows less than 10% activity compared to the wild type enzyme
F237D
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the mutant shows less than 10% activity compared to the wild type enzyme
K62E
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the mutant shows less than 10% activity compared to the wild type enzyme
N244A
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the mutant shows less than 40% activity compared to the wild type enzyme
R236D
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the mutant shows about 80% activity compared to the wild type enzyme
T29V
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the mutant shows about 10% activity compared to the wild type enzyme
additional information
generation of a knockout lcmt1 mutant sbi1, phenotype, overview. PP2A-C methylation status in wild-type and lcmt1 mutant seedlings under control conditions
additional information
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generation of a knockout lcmt1 mutant sbi1, phenotype, overview. PP2A-C methylation status in wild-type and lcmt1 mutant seedlings under control conditions
additional information
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generation of a knockout lcmt1 mutant sbi1, phenotype, overview. PP2A-C methylation status in wild-type and lcmt1 mutant seedlings under control conditions
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additional information
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generation of LCMT1-R71DELTA, a catalytically inactive mutant of LCMT1
additional information
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generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling, circumventing embryonic lethality with Lcmt1 deficiency