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2.1.1.231: flavonoid 4'-O-methyltransferase

This is an abbreviated version!
For detailed information about flavonoid 4'-O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.231

Reaction

S-adenosyl-L-methionine
+
a 4'-hydroxyflavanone
=
S-adenosyl-L-homocysteine
+
a 4'-methoxyflavanone

Synonyms

4'-O-methyltransferase, 4'OMT, B-ring 4'OMT, F 4'-OMT, flavonoid 4'-O-methyltransferase, GerMIII, O-methyltransferase, OMT, regiospecific flavonoid 4'OMT, SOMT-2, SOMT2, soybean O-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.231 flavonoid 4'-O-methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.231 - flavonoid 4'-O-methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4'-hydroxyflavanone + S-adenosyl-L-methionine
4'-methoxyflavanone + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
apigenin + S-adenosyl-L-methionine
acacetin + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
genistein + S-adenosyl-L-methionine
biochanin A + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
kaempferol + S-adenosyl-L-methionine
kaempferide + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + 3'-O-methyleriodictyol
S-adenosyl-L-homocysteine + 3',4'-O-dimethyleriodictyol
show the reaction diagram
-
product identification by mass spectrometry
-
?
S-adenosyl-L-methionine + alizarin
S-adenosyl-L-homocysteine + methylalizarin
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + apigenin
S-adenosyl-L-homocysteine + acacetin
show the reaction diagram
-
36% of the activity relative to naringenin. Escherichia coli harboring SOMT-2 is grown with daidzein, geninstein, apigenin, naringenin, and quercetin, respectively, and reaction products were analyzed with thin layer chromatography and HPLC
-
-
?
S-adenosyl-L-methionine + chrysoeriol
S-adenosyl-L-homocysteine + 4'-O-methylchrysoeriol
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + daidzein
S-adenosyl-L-homocysteine + formononetin
show the reaction diagram
-
90% of the activity relative to naringenin. Escherichia coli harboring SOMT-2 is grown with daidzein, geninstein, apigenin, naringenin, and quercetin, respectively, and reaction products were analyzed with thin layer chromatography and HPLC
-
-
?
S-adenosyl-L-methionine + eriodictyol
S-adenosyl-L-homocysteine + 4'-O-methyleriodictyol
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + fisetin
S-adenosyl-L-homocysteine + 4'-methoxyfisetin
show the reaction diagram
8% activity with fisetin compared to quercetin
-
-
?
S-adenosyl-L-methionine + genistein
S-adenosyl-L-homocysteine + biochanin A
show the reaction diagram
-
62% of the activity relative to naringenin. Escherichia coli harboring SOMT-2 is grown with daidzein, geninstein, apigenin, naringenin, and quercetin, respectively, and reaction products were analyzed with thin layer chromatography and HPLC
-
-
?
S-adenosyl-L-methionine + isorhamnetin
S-adenosyl-L-homocysteine + 4'-O-methylisorhamnetin
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + kaempferol
S-adenosyl-L-homocysteine + 4'-O-methylkaempferol
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + luteolin
S-adenosyl-L-homocysteine + 4'-methoxyluteolin
show the reaction diagram
67% activity with luteolin compared to quercetin
-
-
?
S-adenosyl-L-methionine + myricetin
S-adenosyl-L-homocysteine + 4'-methoxymyricetin
show the reaction diagram
20% activity with luteolin compared to quercetin
-
-
?
S-adenosyl-L-methionine + naringenin
S-adenosyl-L-homocysteine + ponciretin
show the reaction diagram
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + 4'-methoxyquercetin
show the reaction diagram
best substrate, 85% conversion at 2 mM substrate
-
-
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + 4'-methylquercetin
show the reaction diagram
-
Escherichia coli harboring SOMT-2 is grown with daidzein, geninstein, apigenin, naringenin, and quercetin, respectively, and reaction products were analyzed with thin layer chromatography and HPLC
-
-
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + 4'-O-methylquercetin
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + tamarixetin
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + quercetin 3-O-beta-D-glucoside
S-adenosyl-L-homocysteine + 4'-methoxyquercetin 3-O-beta-D-glucoside
show the reaction diagram
16% activity with quercetin glucoside compared to quercetin
-
-
?
additional information
?
-