2.1.1.228: tRNA (guanine37-N1)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (guanine37-N1)-methyltransferase, go to the full flat file.

Reaction

Synonyms

At3g56120, aTrm5a methyltransferase, aTrm5a/Taw22-like enzyme, AtTrm5a, bacterial tRNA (guanine37-N1)-methyltransferase, bacterial tRNA-(N1G37) methyltransferase, EC 2.1.1.31, EcTrmD, HiTrmD, HsTrm5, m1G37 tRNA methyltransferase, m1G37-forming tRNA methyltransferase, Mj-Trm5, MJ0883, MjTrm5, MjTrm5b, mono-functional methyltransferase, More, MtbTrmD, NEQ228, PA14_15990, PAB2272, PAB_RS03940, PaTrm5a, PaTrm5b, PaTrmD, SaTrmD, Ta0997, TAW22, transfer RNA (m1G37) methyltransferase, Trm1, TRM5, Trm5a, Trm5a/Taw22-like enzyme, trm5b, Trm5p, TrmD, TRMT5, tRNA (guanine(37)-N1)-methyltransferase 1, tRNA (guanine37-N1)-methyltransferase, tRNA (guanosine-1) methyltransferase, tRNA (m1G37) methyltransferase, tRNA (m1G37)-methyltransferase, tRNA m1G37 methyltransferase, tRNA methyltransferase, tRNA methyltransferase 5, tRNA methyltransferase D, tRNA(m(1)G37)methyltransferase, tRNA(m1G37) methyltransferase, tRNA(m1G37) MTase, tRNA(m1G37)methyltransferase, tRNA-(N1G37) methyltransferase, tRNAPhe:imG2 methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.228 tRNA (guanine37-N1)-methyltransferase

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Results	in table
1	Activating Compound
43500	AA Sequence
16	Application
31	Cloned(Commentary)
49	Cofactor
17	Crystallization (Commentary)
98	Disease/ Diagnostics
3	Expression
219	General Information
3	General Stability
89	IC50 Value
190	Inhibitors
40	kcat/KM [mM/s]
27	Ki Value [mM]
91	KM Value [mM]
8	Localization
44	Metals/Ions
8	Molecular Weight [Da]
116	Natural Substrates/ Products (Substrates)
168	Organism
3	Pathway
201	PDB ID
29	pH Optimum
5	pH Range
126	Protein Variants
23	Purification (Commentary)
9	Reaction
103	Reference
3	Source Tissue
269	Substrates and Products (Substrate)
58	Subunits
226	Synonyms
1	Systematic Name
28	Temperature Optimum [°C]
3	Temperature Stability [°C]
43	Turnover Number [1/s]

Application

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Application on EC 2.1.1.228 - tRNA (guanine37-N1)-methyltransferase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug development

15 entries

medicine

Methanocaldococcus jannaschii

Q58293

the sequence and structural distinction of bacterial TrmD from the eukaryotic Trm5 suggests that strategies can be developed to specifically inhibit TrmD without a deleterious effect on humans

662622

drug development

Escherichia coli

-

TrmD has potential as a drug target

735927

drug development

Pseudomonas aeruginosa

Q02RL6

the enzyme is a target for antibiotic development

758329

drug development

Pseudomonas aeruginosa

Q02RL6

bacterial tRNA (guanine37-N1)-methyltransferase (TrmD) from Pseudomonas aeruginosa is a good target for development of antibacterial compounds

756152

drug development

Pseudomonas aeruginosa

Q02RL6

bacterial tRNA modification synthesis pathways are critical to cell survival under stress and thus represent ideal mechanism-based targets for antibiotic development. tRNA-(N1G37) methyltransferase (TrmD) is a target, which is conserved and essential in many bacterial pathogens

755697

drug development

Mycobacteroides abscessus

-

the enzyme is an attractive target for development of antibacterial drugs against Mycobacterium abscessus, which possesses both intrinsic and acquired resistance to available antibiotics and is therefore currently difficult or sometimes impossible to treat

757408

drug development

Haemophilus influenzae

A0A0D0GZF5

TrmD is a leading antimicrobial drug target, due to its essentiality for bacterial growth, its broad conservation across bacterial species, and its deep-rooted distinction from the human and archaeal counterpart Trm5, which has the dinucleotide fold

757790

drug development

Aquifex aeolicus

O67463

TrmD is ranked as a high-priority antimicrobial target

756631

drug development

Escherichia coli

P0A873

TrmD is ranked as a high-priority antimicrobial target

756631

drug development

Salmonella enterica subsp. enterica serovar Typhimurium

P36245

TrmD is ranked as a high-priority antimicrobial target

756631

drug development

Haemophilus influenzae

A0A0D0GZF5

TrmD is ranked as a high-priority antimicrobial target

756631

drug development

Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412

-

TrmD is ranked as a high-priority antimicrobial target

-

drug development

Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720

-

TrmD is ranked as a high-priority antimicrobial target

-

drug development

Pseudomonas aeruginosa UCBPP-PA14

-

bacterial tRNA modification synthesis pathways are critical to cell survival under stress and thus represent ideal mechanism-based targets for antibiotic development. tRNA-(N1G37) methyltransferase (TrmD) is a target, which is conserved and essential in many bacterial pathogens

-

drug development

Pseudomonas aeruginosa UCBPP-PA14

-

bacterial tRNA (guanine37-N1)-methyltransferase (TrmD) from Pseudomonas aeruginosa is a good target for development of antibacterial compounds

-

drug development

Pseudomonas aeruginosa UCBPP-PA14

-

the enzyme is a target for antibiotic development

-