2.1.1.226: 23S rRNA (cytidine1920-2'-O)-methyltransferase
This is an abbreviated version!
For detailed information about 23S rRNA (cytidine1920-2'-O)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.226
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2.1.1.226
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aminoglycosides
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amikacin
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carbapenemase
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extended-spectrum
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plasmid-mediated
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esbls
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carbapenem-resistant
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aminoglycoside-modifying
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methylase-producing
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blactx-m
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aac6\'-ib
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aac6\'-ib-cr
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blatem
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blactx-m-15
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aminoglycoside-resistant
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arbekacin
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blakpc-2
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macrolide-lincosamide-streptogramin
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ndm-1-producing
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carbapenemase-producing
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amikacin-resistant
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carbapenemase-encoding
- 2.1.1.226
- aminoglycosides
- amikacin
- carbapenemase
-
extended-spectrum
-
plasmid-mediated
-
esbls
-
carbapenem-resistant
-
aminoglycoside-modifying
-
methylase-producing
-
blactx-m
-
aac6\'-ib
-
aac6\'-ib-cr
-
blatem
- blactx-m-15
-
aminoglycoside-resistant
- arbekacin
- blakpc-2
-
macrolide-lincosamide-streptogramin
-
ndm-1-producing
-
carbapenemase-producing
-
amikacin-resistant
-
carbapenemase-encoding
Reaction
Synonyms
2'-O-methyltransferase, Cj0588, More, rRNA 2'-O-methyltransferase, rRNA methylase, rRNA methylase TlyA, TlyA, TlyAI, TlyAII
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Reference
Reference on EC 2.1.1.226 - 23S rRNA (cytidine1920-2'-O)-methyltransferase
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Maus, C.E.; Plikaytis, B.B.; Shinnick, T.M.
Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis
Antimicrob. Agents Chemother.
49
571-577
2005
Mycobacterium tuberculosis
Johansen, S.K.; Maus, C.E.; Plikaytis, B.B.; Douthwaite, S.
Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs
Mol. Cell
23
173-182
2006
Mycobacterium tuberculosis
Monshupanee, T.; Johansen, S.K.; Dahlberg, A.E.; Douthwaite, S.
Capreomycin susceptibility is increased by TlyA-directed 2-O-methylation on both ribosomal subunits
Mol. Microbiol.
85
1194-1203
2012
Brachyspira hyodysenteriae (Q06803), Geobacillus stearothermophilus, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv, Mycolicibacterium smegmatis (A0QYR0), Mycolicibacterium smegmatis mc(2)155 (A0QYR0), no activity in Escherichia coli, Streptomyces coelicolor, Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Monshupanee, T.
Increased bacterial hemolytic activity is conferred by expression of TlyA methyltransferase but not by its 2'-O-methylation of the ribosome
Curr. Microbiol.
67
61-68
2013
Mycobacterium tuberculosis (P9WJ63), Mycobacterium tuberculosis H37Rv (P9WJ63)
Salamaszynska-Guz, A.; Rose, S.; Lykkebo, C.; Taciak, B.; Bacal, P.; Uspienski, T.; Douthwaite, S.
Biofilm formation and motility are promoted by Cj0588-directed methylation of rRNA in Campylobacter jejuni
Front. Cell. Infect. Microbiol.
7
533
2018
Campylobacter jejuni subsp. jejuni (Q0PAS9), Campylobacter jejuni subsp. jejuni NCTC 11168 (Q0PAS9), Campylobacter jejuni subsp. jejuni ATCC 700819 (Q0PAS9)
Freihofer, P.; Akbergenov, R.; Teo, Y.; Juskeviciene, R.; Andersson, D.; Boettger, E.
Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase
RNA
22
1836-1843
2016
Mycobacterium tuberculosis (P9WJ63), Mycobacterium tuberculosis H37Rv (P9WJ63)
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