2.1.1.223: tRNA1Val (adenine37-N6)-methyltransferase

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For detailed information about tRNA1Val (adenine37-N6)-methyltransferase, go to the full flat file.

Reaction

Synonyms

YfiC

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.223 tRNA1Val (adenine37-N6)-methyltransferase

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Results	in table
6508	AA Sequence
1	Cloned(Commentary)
2	General Information
1	Natural Substrates/ Products (Substrates)
1	Organism
1	Purification (Commentary)
1	Reaction
1	Reference
2	Substrates and Products (Substrate)
1	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 2.1.1.223 - tRNA1Val (adenine37-N6)-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + adenine37 in tRNA1(Val)

S-adenosyl-L-homocysteine + N6-methyladenine37 in tRNA1(Val)

2 entries

S-adenosyl-L-methionine + adenine37 in tRNA1(Val)

S-adenosyl-L-homocysteine + N6-methyladenine37 in tRNA1(Val)

Escherichia coli

P31825

modification of adenine37 in the anticodon loop. The methylation of m6A in tRNA1 Val by YfiC has little influence on the cell growth under standard conditions, the yfiC gene confers a growth advantage under conditions of osmotic and oxidative stress

706723

-

-

?

S-adenosyl-L-methionine + adenine37 in tRNA1(Val)

S-adenosyl-L-homocysteine + N6-methyladenine37 in tRNA1(Val)

Escherichia coli

P31825

unmodified tRNA1(Val) with the anticodon cmo5UAC can be methylated by recombinant YfiC protein in vitro. YfiC methyltransferase can methylate tRNA1(Val), but none of other tRNAs tested (tRNA3(Arg), tRNA1(Glu), tRNA2(Val), tRNA5(Leu), tRNA5(Leu))

706723

-

-

?