2.1.1.222: 2-polyprenyl-6-hydroxyphenol methylase
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For detailed information about 2-polyprenyl-6-hydroxyphenol methylase, go to the full flat file.
Reaction
Synonyms
2-polyprenyl-6-hydroxyphenyl methylase, 3-demethyl ubiquinone-9 3-methyltransferase, UbiG, UbiG methyltransferase, ubiquinone biosynthesis O-methyltransferase
ECTree
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Cloned
Cloned on EC 2.1.1.222 - 2-polyprenyl-6-hydroxyphenol methylase
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expressed in Escherichia coli BL21(DE3) cells
the ubiG gene is able to restore respiration in the yeast coq3 mutant, provided ubiG is modified to contain a mitochondrial leader sequence
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when expressed in multicopy, the human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast