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2.1.1.222: 2-polyprenyl-6-hydroxyphenol methylase

This is an abbreviated version!
For detailed information about 2-polyprenyl-6-hydroxyphenol methylase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
3-(all-trans-polyprenyl)benzene-1,2-diol
=
S-adenosyl-L-homocysteine
+
2-methoxy-6-(all-trans-polyprenyl)phenol

Synonyms

2-polyprenyl-6-hydroxyphenyl methylase, 3-demethyl ubiquinone-9 3-methyltransferase, UbiG, UbiG methyltransferase, ubiquinone biosynthesis O-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.222 2-polyprenyl-6-hydroxyphenol methylase

Cloned

Cloned on EC 2.1.1.222 - 2-polyprenyl-6-hydroxyphenol methylase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
the ubiG gene is able to restore respiration in the yeast coq3 mutant, provided ubiG is modified to contain a mitochondrial leader sequence
-
when expressed in multicopy, the human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast