2.1.1.219: tRNA (adenine57-N1/adenine58-N1)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (adenine57-N1/adenine58-N1)-methyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

Synonyms

bi-specific tRNA adenine-N1, A57-A58-methyltransferase, bi-specific tRNA adenine-N1, A57-A58-MTase, EC 2.1.1.36, PAB0283 protein, PabTrmI, PYRAB04300, TrmI, tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase, tRNA (m1A) methyltransferase, tRNA m1A57/58 methyltransferase, tRNA(m1A57/58)-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.219 tRNA (adenine57-N1/adenine58-N1)-methyltransferase

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Results	in table
257	AA Sequence
2	Cloned(Commentary)
1	Cofactor
2	Crystallization (Commentary)
2	General Information
1	KM Value [mM]
1	Metals/Ions
1	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
8	Organism
1	pH Optimum
2	Protein Variants
4	Purification (Commentary)
1	Reaction
5	Reference
16	Substrates and Products (Substrate)
2	Subunits
19	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.1.219 - tRNA (adenine57-N1/adenine58-N1)-methyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2 S-adenosyl-L-methionine + adenine57/adenine58 in tRNA

2 S-adenosyl-L-homocysteine + N1-methyladenine57/N1-methyladenine58 in tRNA

4 entries

additional information

?

-

3 entries

2 S-adenosyl-L-methionine + adenine57/adenine58 in tRNA

2 S-adenosyl-L-homocysteine + N1-methyladenine57/N1-methyladenine58 in tRNA

Pyrococcus abyssi

Q9V1J7

-

713137

-

-

?

2 S-adenosyl-L-methionine + adenine57/adenine58 in tRNA

2 S-adenosyl-L-homocysteine + N1-methyladenine57/N1-methyladenine58 in tRNA

Pyrococcus abyssi

Q9V1J7

the solvent accessibility of the S-adenosyl-L-methionine pocket is not affected by the tRNA, thereby enabling S-adenosyl-L-homocysteine to be replaced by S-adenosyl-L-methionine without prior release of monomethylated tRNA

730502

-

-

?

2 S-adenosyl-L-methionine + adenine57/adenine58 in tRNA

2 S-adenosyl-L-homocysteine + N1-methyladenine57/N1-methyladenine58 in tRNA

Pyrococcus abyssi GE5 / CNCM I-1302 / DSM 25543

Q9V1J7

the solvent accessibility of the S-adenosyl-L-methionine pocket is not affected by the tRNA, thereby enabling S-adenosyl-L-homocysteine to be replaced by S-adenosyl-L-methionine without prior release of monomethylated tRNA

730502

-

-

?

2 S-adenosyl-L-methionine + adenine57/adenine58 in tRNA

2 S-adenosyl-L-homocysteine + N1-methyladenine57/N1-methyladenine58 in tRNA

Pyrococcus abyssi GE5 / CNCM I-1302 / DSM 25543

Q9V1J7

-

713137

-

-

?

additional information

?

-

Pyrococcus abyssi

Q9V1J7

in most organisms, the widely conserved 1-methyladenosine58 (m1A58) tRNA modification is catalyzed by S-adenosyl-L-methionine-dependent site-specific enzyme TrmI. In archaea, TrmI also methylates the adjacent adenine 57, m1A57 being an obligatory intermediate of 1-methyl-inosine57 formation, multi-site specificity mechanism, overview

730502

-

-

?

additional information

?

-

Pyrococcus abyssi

-

in most organisms, the widely conserved 1-methyladenosine58 (m1A58) tRNA modification is catalyzed by S-adenosyl-L-methionine-dependent site-specific enzyme TrmI. In archaea, TrmI also methylates the adjacent adenine 57, m1A57 being an obligatory intermediate of 1-methyl-inosine57 formation, multi-site specificity mechanism, overview

730502

-

-

?

additional information

?

-

Pyrococcus abyssi GE5 / CNCM I-1302 / DSM 25543

Q9V1J7

in most organisms, the widely conserved 1-methyladenosine58 (m1A58) tRNA modification is catalyzed by S-adenosyl-L-methionine-dependent site-specific enzyme TrmI. In archaea, TrmI also methylates the adjacent adenine 57, m1A57 being an obligatory intermediate of 1-methyl-inosine57 formation, multi-site specificity mechanism, overview

730502

-

-

?