2.1.1.215: tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase

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For detailed information about tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase, go to the full flat file.

Reaction

4 S-adenosyl-L-methionine +

Synonyms

EC 2.1.1.32, multisite-specific tRNA methyltransferase, Trm1, Trm1[tRNA (m2(2)G26) methyltransferase], tRNA (m2(2)G26) methyltransferase, tRNA (N2,N2-guanine)-dimethyltransferase, tRNA:m22G26-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.215 tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase

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Results	in table
88	AA Sequence
4	Cloned(Commentary)
2	Cofactor
1	General Information
1	IC50 Value
1	Inhibitors
15	KM Value [mM]
1	Metals/Ions
7	Natural Substrates/ Products (Substrates)
5	Organism
2	pH Optimum
22	Protein Variants
2	Purification (Commentary)
2	Reaction
5	Reference
23	Substrates and Products (Substrate)
1	Subunits
11	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 2.1.1.215 - tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

AdoEnYn

Pyrococcus furiosus

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a double-activated AdoMet analogue containing a pent-2-en-4-ynyl (EnYn) side chain instead of the methyl group. The double bond in beta-position to the sulfonium center counteracts unfavorable steric interactions within the SN2-like transition by conjugative stabilization and the terminal alkyne serves as reactive bio-orthogonal functionality. tRNAPhe methylation reaction to be inhibited by micromolar concentrations of AdoEnYn. EnYn-modified RNA structure determination by mass spectrometry

720588