2.1.1.214: tRNA (guanine10-N2)-methyltransferase

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For detailed information about tRNA (guanine10-N2)-methyltransferase, go to the full flat file.

Reaction

Synonyms

(m2G10) methyltransferase, archaeal Trm11, EC 2.1.1.32, eukaryotic m2G10 tRNA methyltransferase, eukaryotic Trm11, N2, N2-dimethylguanosine tRNA methyltransferase, N2,N2-dimethylguanosine tRNA methyltransferase, Tk0981, Trm-G10, Trm-m22G10, Trm11, Trm11-Trm112 complex, Trm11p, Trmp112p, tRNA m2G10/m22G10 methyltransferase, tRNA MTase, YOL124c

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.214 tRNA (guanine10-N2)-methyltransferase

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Results	in table
1	Activating Compound
19	AA Sequence
4	Cloned(Commentary)
4	Cofactor
16	General Information
1	Inhibitors
1	KM Value [mM]
1	Localization
4	Metals/Ions
1	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
8	Organism
1	Pathway
2	pH Optimum
4	Protein Variants
2	Purification (Commentary)
1	Reaction
8	Reference
3	Source Tissue
13	Substrates and Products (Substrate)
5	Subunits
33	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Cloned

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Cloned on EC 2.1.1.214 - tRNA (guanine10-N2)-methyltransferase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

gene Tk0981

Thermococcus kodakarensis

Q5JID5

757106

gene TRM112, phylogenetic analysis, expression of His-tagged Trm112p, alone or with Trm9p, in Escherichia coli strain S15 (DE3-pLysS), Trm112p forms a complex with Trm9p, which renders the latter soluble

Saccharomyces cerevisiae

-

712436

gene YOL124c, recombinant expression of soluble C-terminally His6-tagged wild-type and mutant enzymes in Escherichia coli strain BL21-Gold (DE3), coexpression of yeast Trm11 with yeast Trm112 in Escherichia coli, the holonezyme complex is active

Saccharomyces cerevisiae

Q12463

757844

recombinant Trm11p expressed in Escherichia coli exhibited no m2G10 formation activity. Trm112p and Trm11p are both required for the formation of m2G10 in vivo as well as in vitro

Saccharomyces cerevisiae

Q12463

675961