2.1.1.213: tRNA (guanine10-N2)-dimethyltransferase

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For detailed information about tRNA (guanine10-N2)-dimethyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

Synonyms

EC 2.1.1.32, N(2),N(2)-dimethylguanosine tRNA methyltransferase, PAB1283, PabTrm-G10, PabTrm-m2 2G10 enzyme, Trm-G10, tRNA:m2(2)G10 methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.213 tRNA (guanine10-N2)-dimethyltransferase

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Results	in table
321	AA Sequence
2	Cloned(Commentary)
1	Metals/Ions
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
3	Organism
1	pH Optimum
2	Purification (Commentary)
5	Reaction
3	Reference
5	Substrates and Products (Substrate)
1	Subunits
8	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.1.213 - tRNA (guanine10-N2)-dimethyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2 S-adenosyl-L-methionine + guanine10 in tRNA

2 S-adenosyl-L-homocysteine + N2-dimethylguanine10 in tRNA

Pyrococcus abyssi

Q9UY84

depending on the experimental conditions used, as well as the tRNA substrate tested, the enzymatic reaction leads to the formation of either N2-methyl or N2-dimethylguanosine. N2-Dimethylguanine10 accumulates during incubation at 50°C, whereas the formation of N2-methylguanine10 appears to be a transient intermediate. At 30°C, N2-dimethylguanine10 is efficiently formed, whereas the formation of N2-methylguanine10 is considerably slowed compared with that at higher temperatures

659377

-

-

?

S-adenosyl-L-methionine + guanine10 in tRNA

S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA

Pyrococcus abyssi

Q9UY84

depending on the experimental conditions used, as well as the tRNA substrate tested, the enzymatic reaction leads to the formation of either N2-methyl or N2-dimethylguanosine. N2-Dimethylguanine10 accumulates during incubation at 50°C, whereas the formation of N2-methylguanine10 appears to be a transient intermediate. At 30°C, N2-dimethylguanine10 is efficiently formed, whereas the formation of N2-methylguanine10 is considerably slowed compared with that at higher temperatures

659377

-

-

?