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2.1.1.209: 23S rRNA (guanine2535-N1)-methyltransferase

This is an abbreviated version!
For detailed information about 23S rRNA (guanine2535-N1)-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
guanine2535 in 23S rRNA
=
S-adenosyl-L-homocysteine
+
N1-methylguanine2535 in 23S rRNA

Synonyms

AviRa

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.209 23S rRNA (guanine2535-N1)-methyltransferase

Systematic Name

Systematic Name on EC 2.1.1.209 - 23S rRNA (guanine2535-N1)-methyltransferase

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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:23S rRNA (guanine2535-N1)-methyltransferase
Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (guanine2535-N1)-methyltransferase and EC 2.1.1.208 [23S rRNA (uridine2479-2-O)-methyltransferase], whose actions confer avilamycin resistance to the RNA.