2.1.1.208: 23S rRNA (uridine2479-2'-O)-methyltransferase

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For detailed information about 23S rRNA (uridine2479-2'-O)-methyltransferase, go to the full flat file.

Reaction

Synonyms

AviRb

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.208 23S rRNA (uridine2479-2'-O)-methyltransferase

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Results	in table
465	AA Sequence
2	Cloned(Commentary)
1	Crystallization (Commentary)
1	General Stability
3	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
4	Organism
1	pH Optimum
7	Protein Variants
2	Purification (Commentary)
1	Reaction
4	Reference
4	Substrates and Products (Substrate)
1	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.1.1.208 - 23S rRNA (uridine2479-2'-O)-methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:23S rRNA (uridine2479-2'-O)-methyltransferase

Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (uridine2479-2'-O)-methyltransferase and EC 2.1.1.209 [23S rRNA (guanine2535-N1)-methyltransferase], whose actions confer avilamycin resistance to the RNA.