2.1.1.208: 23S rRNA (uridine2479-2'-O)-methyltransferase
This is an abbreviated version!
For detailed information about 23S rRNA (uridine2479-2'-O)-methyltransferase, go to the full flat file.
Reaction
Synonyms
AviRb
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.208 - 23S rRNA (uridine2479-2'-O)-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + uridine2479 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA
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S-adenosyl-L-methionine + uridine2479 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA
AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of uridine2479 of the 23S ribosomal RNA in Gram-positive bacteria and thus mediates resistance to the oligosaccharide antibiotic avilamycin
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S-adenosyl-L-methionine + uridine2479 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA
AviRb modifies the 2'-O-ribose position of nucleotide uridine2479 within helix 89
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S-adenosyl-L-methionine + uridine2479 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA
AviRb modifies the 2'-O-ribose position of nucleotide uridine2479 within helix 89. The exact position of the modification is conformed by MALDI mass spectrometry, a single methyl group is added. No methylation activity with 16S rRNA
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