2.1.1.204: tRNA (cytosine38-C5)-methyltransferase
This is an abbreviated version!
For detailed information about tRNA (cytosine38-C5)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.204
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2.1.1.204
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methyltransferases
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n6-methyladenosine
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5-methylcytosine
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mtases
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2'-o-methylation
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epitranscriptomic
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methyltransferase-like
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2'-o-methyltransferase
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piwi-interacting
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mettl16
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spout
- 2.1.1.204
- methyltransferases
- n6-methyladenosine
- 5-methylcytosine
- mtases
-
2'-o-methylation
-
epitranscriptomic
-
methyltransferase-like
-
2'-o-methyltransferase
-
piwi-interacting
- mettl16
-
spout
Reaction
Synonyms
(cytosine-5) RNA methyltransferase, cytosine-5 tRNA methyltransferase, dDnmt2, DNA methyltransferase 2, DnmA, Dnmt2, DNMT2 methyltransferase, EC 2.1.1.29, hDNMT2, Pf-DNMT2, PMT1, pombe methyltransferase 1, RCMT, RNA methyltransferase, spDnmt2, transfer RNA aspartic acid methyltransferase 1, TRDMT1, tRNA aspartic acid methyltransferase 1, tRNA-aspartic acid methyltransferase 1
ECTree
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Source Tissue
Source Tissue on EC 2.1.1.204 - tRNA (cytosine38-C5)-methyltransferase
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Dnmt2-EGFP is highly expressed in the germarium, blastocyst and cyst stages of the female germ line with the exception of follicle cells. Dnmt2-EGFP is mostly present in the cytoplasm but can also be found in nurse cell nuclei. In the male germ line, Dnmt2-EGFP is expressed in most cells, including stem cells as well as in maturing spermatocytes with the exception of the post-mitotic hub cells
Lin(neg) Sca1+cKit+ haematopoietic progenitor cells that represent a heterogeneous cell population containing the most primitive haematopoietic cells that have self-renewal capacity and haematopoietic progenitors that give rise to all mature cell types found in peripheral blood for a lifetime
additional information
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early, DNMT2 gene transcript in bovine preimplantation embryos is expressed at the 2-cell, 4-cell, 8-cell, 16-cell, morula and blastocyst stage embryos
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ubiquitously expressed during early embryogenesis. Expression remains ubiquitous throughout development with enrichment in the foregut and hindgut as well as in the developing mesoderm in gastrulating embryos. Dnmt2 proteins are enriched in actively dividing cells. Dnmt2 localization is highly dynamic during the cell cycle
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the Dnmt2 mRNA is present at very low levels during early bovine preimplantation development, but its expression remarkably increases at morula stage, developmental expression analysis of DNMT2, overview
additional information
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Dnmt2 is consistently upregulated in hundreds of tumor samples
additional information
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in humans, DNMT2 mRNA is not transcribed in either any follicular stages of primordial, primary and secondary or in the GV, MI, and MII oocytes at Day 0 or Day 1, except for presence of a limited expression of DNMT2 in the MII oocytes, developmental expression analysis of DNMT2, overview
additional information
expression of DNMTs in spermatogenetic cells in humans, enzyme DNMT2 is not involved, in contrast to the other DNMTs, overview
additional information
developmental expression analysis of DNMT2, overview
additional information
enzyme Dnmt2 is expressed in various mouse tissues
additional information
expression of DNMTs in spermatogenetic cells in mice, enzyme DNMT2 is not involved, in contrast to the other DNMTs, overview