2.1.1.202: multisite-specific tRNA:(cytosine-C5)-methyltransferase

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Word Map on EC 2.1.1.202

2.1.1.202

methyltransferases

mtases

methylome

williams-beuren

anticodon

transcriptome-wide

Reaction

Synonyms

5-methylcytosine RNA methyltransferase, broad-spectrum methyltransferase, cytosine-5 RNA methyltransferase, EC 2.1.1.29, HNSun6, M5C RNA methyltransferase, MJ0026, multisite-specific tRNA:m5C-methyltransferase, Ncl1p, NOP2/Sun RNA methyltransferase 2, NSUN2, NSUN6, PhNSUN6, RNA (cytosine-5)-methyltransferase, RNA:m5C methyltransferase, RNA:m5C MTase, TRDMT1, TRM4, TRM4A, TRM4B, Trm4p, tRNA (cytosine72-C5)-methyltransferase, tRNA-specific methyltransferase 4B, tRNA:m5C-methyltransferase, tRNA:m5C72 MTase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.202 multisite-specific tRNA:(cytosine-C5)-methyltransferase

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Results	in table
1	Activating Compound
22	AA Sequence
2	Application
5	Cloned(Commentary)
22	Cofactor
3	Crystallization (Commentary)
62	Disease/ Diagnostics
5	Expression
71	General Information
4	Inhibitors
1	KM Value [mM]
13	Localization
3	Metals/Ions
3	Molecular Weight [Da]
151	Natural Substrates/ Products (Substrates)
110	Organism
1	Pathway
8	pH Optimum
30	Protein Variants
3	Purification (Commentary)
12	Reaction
37	Reference
35	Source Tissue
190	Substrates and Products (Substrate)
3	Subunits
88	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]

Expression

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Expression on EC 2.1.1.202 - multisite-specific tRNA:(cytosine-C5)-methyltransferase

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exposure to oxidative stress efficiently repressed NSUN2, causing a reduction of methylation at specific tRNA sites. Nucleophosmin (NPMI) is a marker for nucleolar stress, and a rapid, strong down-regulation of both NPMI and NSUN2 is observed upon arsenite treatment. Additional NSUN family members residing in the mitochondria (NSUN3, NSUN4) and cytoplasm (NSUN6) are similarly repressed in response to arsenite stress

2 entries

levels of tRNAHis m5C increase following several nutrient starvation treatments of the BY4741 strain, Trm4 protein levels do not increase during starvation conditions

2 entries

sequenced cDNA libraries prepared from small RNA isolated from NSUN2+/- and NSUN2-/- human fibroblasts reveal that eight of the 43 ncRNAs are differentially regulated

Homo sapiens

735907