2.1.1.2: guanidinoacetate N-methyltransferase
This is an abbreviated version!
For detailed information about guanidinoacetate N-methyltransferase, go to the full flat file.
Reaction
Synonyms
GA methylpherase, GAA methyltransferase, GAMT, guanidinoacetate methyltransferase, guanidinoacetate N-methyltransferase, guanidinoacetate transmethylase, guanidoacetate methyltransferase, methionine-guanidinoacetic transmethylase, MIM 601240, N-guanidinoacetate methyltransferase, S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.2 - guanidinoacetate N-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + guanidinoacetic acid + glutathione
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assay at pH 7.4, 37°C, 1 h, reaction stopped with 5% trichloroacetic acid
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S-adenosyl-L-homocysteine + creatine
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S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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S-adenosyl-L-methionine is the only possible methyl donor
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S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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biosynthesis of creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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S-adenosyl-L-methionine is the only possible methyl donor
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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biosynthesis of creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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S-adenosyl-L-methionine is the only possible methyl donor
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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biosynthesis of creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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ir
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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S-adenosyl-L-methionine is the only possible methyl donor
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?
S-adenosyl-L-methionine + guanidinoacetate
S-adenosyl-L-homocysteine + creatine
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biosynthesis of creatine
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since the L197P mutation in the exon 6 of the guanidinoacetate N-methyltransferase gene leaves the isoform B of the enzyme unaffected, the occurrence of biochemical alterations and disease in this subject testifies against the possibility that isoform B has guanidinoacetate N-methyltransferase activity
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additional information
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together with creatine/phosphocreatine shuttle system involved in brain energy homeostasis through a neuron-glial relationship
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