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2.1.1.2: guanidinoacetate N-methyltransferase

This is an abbreviated version!
For detailed information about guanidinoacetate N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.2

Reaction

S-adenosyl-L-methionine
+
Guanidinoacetate
=
S-adenosyl-L-homocysteine
+
Creatine

Synonyms

GA methylpherase, GAA methyltransferase, GAMT, guanidinoacetate methyltransferase, guanidinoacetate N-methyltransferase, guanidinoacetate transmethylase, guanidoacetate methyltransferase, methionine-guanidinoacetic transmethylase, MIM 601240, N-guanidinoacetate methyltransferase, S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.2 guanidinoacetate N-methyltransferase

Source Tissue

Source Tissue on EC 2.1.1.2 - guanidinoacetate N-methyltransferase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
weak GAMT expression is detected in the epithelium of alimentary tract
Manually annotated by BRENDA team
-
highest enzyme level
Manually annotated by BRENDA team
in embryos at 12.5 days of gestation guanidinoacetate N-methyltransferase is detectable in the hepatic primordium only, with all other tissues being negative. Non-radioactive in situ hybridization (58°C for 40 h in 5 x SSC, 50% formamide and 40 microg/ml salmon sperm DNA) with digoxigenin-labeled antisense and sense riboprobes (400 ng/ml) for rat guanidinoacetate N-methyltransferase. guanidinoacetate N-methyltransferase proteins are detected with rabbit polyclonal antibodies
Manually annotated by BRENDA team
in embryos at 18.5 days of gestation guanidinoacetate N-methyltransferase is detectable. Non-radioactive in situ hybridization (58°C for 40 h in 5 x SSC, 50% formamide and 40 microg/ml salmon sperm DNA) with digoxigenin-labeled antisense and sense riboprobes (400 ng/ml) for rat guanidinoacetate N-methyltransferase. guanidinoacetate N-methyltransferase proteins are detected with rabbit polyclonal antibodies
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
GAMT is strongly expressed in all neurons and glia cells of neural cord
Manually annotated by BRENDA team
-
low enzyme level
Manually annotated by BRENDA team
GAMT is highly expressed in perivascular pericytes and smooth muscle cells after birth
Manually annotated by BRENDA team
-
S180 cells
Manually annotated by BRENDA team
GAMT was highly expressed in perivascular pericytes and smooth muscle cells after birth
Manually annotated by BRENDA team
-
mainly found in Sertoli cells of seminiferous tubules
Manually annotated by BRENDA team
-
L197P mutation in exon 6: guanidinoacetate increases to 2566 microMol/l, creatine decreases to 3.7 microMol/l
Manually annotated by BRENDA team
-
low enzyme level
Manually annotated by BRENDA team
additional information