2.1.1.197: malonyl-[acyl-carrier protein] O-methyltransferase
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For detailed information about malonyl-[acyl-carrier protein] O-methyltransferase, go to the full flat file.
Reaction
Synonyms
BioC, S-adenosyl-L-methionine-dependent methyltransferase, SAM-dependent methyltransferase
ECTree
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Systematic Name
Systematic Name on EC 2.1.1.197 - malonyl-[acyl-carrier protein] O-methyltransferase
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S-adenosyl-L-methionine:malonyl-[acyl-carrier protein] O-methyltransferase
Involved in an early step of biotin biosynthesis in Gram-negative bacteria. This enzyme catalyses the transfer of a methyl group to the omega-carboxyl group of malonyl-[acyl-carrier protein] forming a methyl ester. The methyl ester is recognized by the fatty acid synthetic enzymes, which process it via the fatty acid elongation cycle to give pimelyl-[acyl-carrier-protein] methyl ester [5]. While the enzyme can also accept malonyl-CoA, it has a much higher activity with malonyl-[acyl-carrier protein] [6]