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2.1.1.197: malonyl-[acyl-carrier protein] O-methyltransferase

This is an abbreviated version!
For detailed information about malonyl-[acyl-carrier protein] O-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
malonyl-[acyl-carrier protein]
=
S-adenosyl-L-homocysteine
+
malonyl-[acyl-carrier protein] methyl ester

Synonyms

BioC, S-adenosyl-L-methionine-dependent methyltransferase, SAM-dependent methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.197 malonyl-[acyl-carrier protein] O-methyltransferase

Systematic Name

Systematic Name on EC 2.1.1.197 - malonyl-[acyl-carrier protein] O-methyltransferase

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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:malonyl-[acyl-carrier protein] O-methyltransferase
Involved in an early step of biotin biosynthesis in Gram-negative bacteria. This enzyme catalyses the transfer of a methyl group to the omega-carboxyl group of malonyl-[acyl-carrier protein] forming a methyl ester. The methyl ester is recognized by the fatty acid synthetic enzymes, which process it via the fatty acid elongation cycle to give pimelyl-[acyl-carrier-protein] methyl ester [5]. While the enzyme can also accept malonyl-CoA, it has a much higher activity with malonyl-[acyl-carrier protein] [6]