2.1.1.192: 23S rRNA (adenine2503-C2)-methyltransferase

This is an abbreviated version!
For detailed information about 23S rRNA (adenine2503-C2)-methyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

Synonyms

Cfr, EC 2.1.1.194, methyltransferase YfgB/RlmN, NlmA, radical AdoMet rRNA methyltransferase, radical S-adenosyl-L-methionine enzyme, radical SAM enzyme, RlmN, RlmN methyltransferase, YfgB, YfgB/RlmN

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.192 23S rRNA (adenine2503-C2)-methyltransferase

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Results	in table
34943	AA Sequence
7	Cloned(Commentary)
19	Cofactor
4	Crystallization (Commentary)
25	General Information
1	KM Value [mM]
3	Metals/Ions
3	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
23	Organism
8	PDB ID
1	pH Optimum
14	Protein Variants
2	Purification (Commentary)
8	Reaction
22	Reference
40	Substrates and Products (Substrate)
3	Subunits
29	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Natural Substrates Products

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of the Enzyme Summary Page.

Natural Substrates Products on EC 2.1.1.192 - 23S rRNA (adenine2503-C2)-methyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

4 entries

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin

Staphylococcus aureus

-

-

736280

-

-

?

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin

2 entries

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin

4 entries

2 S-adenosyl-L-methionine + adenine37 in tRNA + 2 reduced [2Fe-2S] ferredoxin

2 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine37 in tRNA + 2 oxidized [2Fe-2S] ferredoxin

2 entries

S-adenosyl-L-methionine + adenine2503 in 23S rRNA

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

5 entries

additional information

?

-

2 entries

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

Escherichia coli

-

-

721038

-

-

?

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

Escherichia coli

-

the enzyme catalyzes the natural post-transcriptional modification of A2503 to m2A in Escherichia coli 23S rRNA

706722

-

-

?

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

Escherichia coli K-12

P36979

RlmN is an endogenous enzyme used by the cell to refine functions of the ribosome in protein synthesis

704203

-

-

?

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

Staphylococcus aureus

-

-

718586

-

-

?

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin

Escherichia coli

P36979

-

758141, 758461, 758463

-

-

?

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin

Mammaliicoccus sciuri

A0A1X0U0N1

-

758128

-

-

?

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin

Bacillus subtilis

O34617

-

733111

-

-

?

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin

Bacillus subtilis 168

O34617

-

733111

-

-

?

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin

Thermus thermophilus

Q5SGZ3

-

733111

-

-

?

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin

Thermus thermophilus HB8 / ATCC 27634 / DSM 579

Q5SGZ3

-

733111

-

-

?

2 S-adenosyl-L-methionine + adenine37 in tRNA + 2 reduced [2Fe-2S] ferredoxin

2 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine37 in tRNA + 2 oxidized [2Fe-2S] ferredoxin

Escherichia coli

P36979

-

758141, 758461, 758463

-

-

?

2 S-adenosyl-L-methionine + adenine37 in tRNA + 2 reduced [2Fe-2S] ferredoxin

2 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine37 in tRNA + 2 oxidized [2Fe-2S] ferredoxin

Mammaliicoccus sciuri

A0A1X0U0N1

-

758128

-

-

?

S-adenosyl-L-methionine + adenine2503 in 23S rRNA

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

Escherichia coli

-

the enzyme only catalyzes C2 methylation of adenine2503 in 23S rRNA

734031

-

-

?

S-adenosyl-L-methionine + adenine2503 in 23S rRNA

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

Escherichia coli

-

the enzyme primarily methylates C-8 in A2503 of 23S rRNA

733111

-

-

?

S-adenosyl-L-methionine + adenine2503 in 23S rRNA

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

Mammaliicoccus sciuri

Q9FBG4

-

735095

-

-

?

S-adenosyl-L-methionine + adenine2503 in 23S rRNA

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

Mammaliicoccus sciuri

Q9FBG4

the enzyme primarily methylates C-8 in A2503 of 23S rRNA

733111

-

-

?

S-adenosyl-L-methionine + adenine2503 in 23S rRNA

S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

Staphylococcus aureus

-

the enzyme methylates C8 in adenine2503 in 23S rRNA

734749

-

-

?

additional information

?

-

Escherichia coli

-

RlmN introduces m2A at position 2503 in the peptidyl transferase center of 23S RNA. RlmN is a dual-specificity enzyme that catalyzes methylation of both rRNA and tRNA, see for EC 2.1.1.66, substrate specificity analysis, overview

721038

-

-

?

additional information

?

-

Staphylococcus aureus

-

methylation at C2 is similar to that at C8, cf. EC 2.1.1.224

736280

-

-

?