2.1.1.191: 23S rRNA (cytosine1962-C5)-methyltransferase
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For detailed information about 23S rRNA (cytosine1962-C5)-methyltransferase, go to the full flat file.
Reaction
Synonyms
RlmI, rRNA large subunit methyltransferase I, YccW
ECTree
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General Information
General Information on EC 2.1.1.191 - 23S rRNA (cytosine1962-C5)-methyltransferase
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evolution
malfunction
possible evolutionary relationships of the enzyme is discussed
evolution
YccW directed methylation at nucleotide C1962 is conserved in bacteria
a mutant with a deletion of rlmI shows a significant decrease in biofilm formation
malfunction
inactivation of the yccW gene leads to loss of methylation at nucleotide 1962 in Escherichia coli 23S rRNA. This methylation is restored by complementing the knockout strain with a plasmid-encoded copy of the yccW gene. Loss of this methylation in Escherichia coli results in a slight growth defect compared to wild-type cells during competitive growth experiments in rich or minimal medium